HISTONE DEACETYLASE INHIBITORS MARKET ANALYSIS

Market Challenges And Opportunities

Global Histone Deacetylase Inhibitors Market Drivers

Research and development activities related to HDACs are expected to propel the global histone deacetylase inhibitors market growth. For instance, in May 2018, EddingPharm Oncology Co. Ltd. and Syndax Pharmaceuticals, Inc. commenced a study on combination of exemestane and entinostat (HDAC) for the treatment of advanced breast cancer in Chinese patients. Exemestane lowers the level of estrogen (it drives the breast cancer cell growth) and entinostat is expected to enhance the anti-tumor effect of exemestane. Currently, it’s in the third phase of clinical trials and is being studied for the safety and efficacy of the combined drugs.

Furthermore, in June 2016, The Netherlands Cancer Institute commenced a clinical trial study of vorinostat, a drug for the treatment of skin neoplasms. It is being studied for the safety and efficacy, and around 22 participants are involved in it. Currently, it is in the second phase of clinical trial. Such research activities are expected to accelerate the global histone deacetylase inhibitors market growth.

Approvals of the drugs related to histone deacetylases from regulatory bodies are expected to boost the global histone deacetylase inhibitors market growth. For instance, in February 2015, Novartis AG received approval for Farydak from U.S. Food & Drug Administration (FDA). It is being used for the treatment of patients with multiple myeloma. It is approved for the treatment in combination with bortezomib and dexamethasone. Farydak is the first HDAC inhibitor to receive an approval for the treatment of multiple myeloma. These factors are expected to propel the global histone deacetylase market growth.

Global Histone Deacetylase Inhibitors Market Restraints

Side effects associated with the inhibitors of HDAC may hamper the global histone deacetylase inhibitors market growth. Farydak can have side effects such as severe diarrhea, fatal cardiac events, and arrhythmia while Zolinza can cause swelling on face, lip, etc., clotting of blood in legs or lungs, and sometimes difficulty in breathing. These side effects may obstruct the global histone deacetylase inhibitors market growth.