Global Gel Permeation Chromatography Market Is Estimated To Witness High Growth Owing To Rising Pharmaceutical Sector Participation & Significant Global Gel Permeation Chromatography Market Applications In Biotechnology
The Global Gel Permeation Chromatography Market is estimated to be valued at USD 1.60 Bn in 2024, exhibiting a CAGR of 7.4% over the forecast period (2024-2031). The increasing usage of gel permeation chromatography in the pharmaceutical industry for developing new drugs is driving the market growth. Furthermore, rising adoption of GPC in biotechnology applications is further augmenting the market growth.
Market Dynamics:
Gel permeation chromatography finds vast application in the pharmaceutical industry for the development and quality analysis of drugs. It helps in determining the molecular weight distribution and particle size of polymers used in drug manufacturing. Thus, increasing R&D expenditure and new drug development by pharmaceutical players are fueling the adoption of GPC systems. Gel permeation chromatography techniques help in separation, identification, and characterization of biomolecules like proteins and nucleic acids. It enables studying biomolecular assemblies and complexes, which has wide utility in fields like genomics, proteomics, and immunology. Thus, extensive research in biotechnology is propelling the market growth.
Increasing Demand for Characterization of Biotherapeutics is Driving Growth in the Global Gel Permeation Chromatography Market
The growing demand for the characterization of biotherapeutics such as monoclonal antibodies, vaccines, and recombinant proteins is a major driver for the global gel permeation chromatography market. Biotherapeutics offer high potential for the treatment of various diseases such as cancer and autoimmune disorders. However, characterization of complex biomolecules requires sophisticated analytical techniques like gel permeation chromatography to analyze various attributes such as molecular weight distribution, aggregation, and purity. Gel permeation chromatography has emerged as a gold standard technique for analyzing biotherapeutics due to its ability to separate biomolecules based on their size and hydrodynamic radius. It provides accurate and reproducible results for quality assurance during drug development and manufacturing. With the biotherapeutics industry is expected to grow at a rapid pace in the coming years due to rising demand for protein-based drugs and vaccines, need for gel permeation chromatography for characterization and quality testing of these molecules will also increase significantly.
Adoption of Multi-Detector Gel Permeation Chromatography Systems is Driving Stronger Market Growth
Gel permeation chromatography systems integrated with multiple detectors such as refractive index detector, UV detector, light scattering detector, and viscosity detector are gaining widespread adoption. These multi-detector systems provide comprehensive characterization of samples by simultaneously measuring attributes like molecular weight, size distribution, and concentration without any data normalization. They help obtain in-depth insight into sample purity and quality with just a single run.
The ability of multi-detector GPC systems to streamline analysis and generate reproducible, reliable results with high sensitivity and precision is boosting their popularity among companies in the pharmaceutical, biotechnology, and polymer industries. System vendors are also increasingly offering hyphenated techniques by combining GPC with mass spectrometry, further enhancing analytical capabilities. This shift towards multi-dimensional analysis is fueling revenue growth in the gel permeation chromatography market.
High Capital Investment Requirement is a Major Market Restraint
Gel permeation chromatography systems coupled with innovative detectors require substantial upfront capital investment. For instance, a basic single detector GPC set up may cost over US$ 100,000 while a leading-edge multi-detector chromatography unit can exceed US$ 300,000. Moreover, operating costs for consumables like columns and solvents add to the expenses. The high capital requirement poses a major challenge, especially for small and medium-sized labs and companies with limited budgets.
This acts as a barrier to the procurement of advanced chromatography technologies. System leasing options by OEMs help alleviate the costs to some extent but long payback periods continue to discourage many potential buyers. Stringent validation and qualitative performance requirements after installation also entail additional monitoring and maintenance costs over the product lifecycle. All these factors make gel permeation chromatography a costly proposition for some segments of the user base.
Shortage of Skilled Professionals Hinders Market Potential
Gel permeation chromatography demands specialized training to install, optimize, and conduct quantitative analysis using the equipment. However, there is a growing deficit of adequately qualified and experienced chromatography scientists and technicians across major countries. Lack of focused educational programs churning out GPC experts has created a talent crunch.
This shortage of skilled human resources limits the number of samples that can be analyzed as well as the operational efficiency of existing chromatography infrastructure. It also holds back the transfer of advanced multi-detector technologies in some regions. Chromatography product vendors and service providers are investing in training initiatives to bridge this skill gap. But it will take considerable time before an ample workforce with suitable GPC expertise is available worldwide to unleash the technology's full potential applications.
Increasing R&D Spending on Polymers and Advanced Materials Spurs Opportunities
Rising global R&D expenditures on new polymers, composites, and specialty materials fuel opportunities for gel permeation chromatography. Characterization and quality analysis of polymers and advanced materials usually require comprehensive molecular weight distribution and structure-property correlation studies which are best achieved through GPC.
Polymer and material scientists are exploiting the capabilities of hyphenated GPC-MS/GPC-IR systems to derive novel insights into materials functionality at a molecular level. Growing demand from additive manufacturing and green materials sectors also presents lucrative prospects. Emerging applications in molecularly imprinted polymers and block co-polymers synthesis offer scope to drive the global gel permeation chromatography market as they involve extensive analytical characterization stages. Overall, innovation in polymers and materials R&D acts as a key growth lever.
Link: https://www.coherentmarketinsights.com/market-insight/gel-permeation-chromatography-market-28
Key Developments:
- In June 2023, Agilent Technologies showcased its expanded InfinityLab Gel Permeation Chromatography/Size Exclusion Chromatography (GPC/SEC) Solution at High-Performance Liquid Chromatography (HPLC) 2023 in Düsseldorf, Germany. Incorporating products from its acquisition of Polymer Standards Service Ltd. (PSS), the portfolio now includes a GPC/SEC Column Thermostat, Multi-Angle Light Scattering (MALS) Detector, GPC/SEC-Ready Kit, and WinGPC Software.
- In August 2022, Agilent Technologies acquired Polymer Standards Service GmbH (PSS), a leader in polymer characterization solutions. The acquisition strengthened Agilent Technologies portfolio in gel permeation chromatography (GPC) and size exclusion chromatography (SEC), benefiting industries like biopharmaceuticals and chemicals. Agilent Technologies aims to leverage its global reach to expand PSS’s advanced hardware, software, and materials to a broader market.
- In June 2022, Bio-Rad Laboratories, an U.S.-based developer and manufacturer of specialized technological products, introduced EconoFit Low-Pressure Prepacked Chromatography Column Packs for resin screening in protein purification workflows. The packs include mixed-mode, cation, and anion exchange resins, as well as columns for His-tag protein purification, available in 1 ml and 5 ml sizes.
Key Players:
Waters Corporation, Shimadzu Corporation, Agilent Technologies, Malvern Instruments, TOSOH Corporation, Schambeck SFD, Polymer Char, J2 Scientific, Gilson, Inc., LC Tech, Labtech International, PerkinElmer, Inc., Thermo Fisher Scientific, Bio-Rad Laboratories, and Sartorius AG
