Global DNA repair drugs market is estimated to witness high growth, owing to rapid advancement in healthcare infrastructure & rising prevalence of cancer
Global DNA repair drugs market is estimated to be valued at USD 7.10 Bn in 2024, exhibiting a CAGR of 13.1% over the forecast period 2024-2031. Increasing research and development activities for development of innovative drugs along with rising investment in healthcare infrastructure can drive the market growth.
Market Dynamics:
Global DNA repair drugs market growth is primarily driven by rapid advancement in healthcare infrastructure and rising prevalence of cancer globally. Improvement in healthcare infrastructure has increased the access to advanced treatment options such as DNA repair drugs for cancer patients. According to WHO, cancer burden is expected to increase by 70% by 2030. Increasing per capita healthcare expenditure has enhanced the adoption of newly developed DNA repair drugs for effective cancer management. Furthermore, ongoing clinical trials exploring the potential of DNA repair pathways for various cancers can offer new opportunities in the near future. However, high costs associated with drug development and lack of awareness in low-income countries can hamper the market growth.
Rising prevalence of DNA damaging diseases can drive the market growth
Rising prevalence of various cancers and neurodegenerative diseases can drive the DNA repair drugs market growth. DNA damage caused due to external factors such as UV exposure, pollution, lifestyle habits like smoking and consumption of processed foods has led to a rise in cases of cancer. According to WHO, cancer burden is expected to grow to 27.5 million new cases and 16.3 million cancer deaths by 2040. Similarly, neurological disorders like Alzheimer's and Parkinson's diseases are rising due to faulty DNA repair mechanisms in the brain and nervous system. DNA repair drugs aim to identify and fix damaged DNA, thus, preventing the progression of such chronic and life-threatening illnesses. This growing disease burden worldwide can boost demand for innovative DNA repair therapies.
Advancements in genome sequencing technologies boosts drug development
Rapid technological advancements in fields such as genome sequencing, molecular diagnostics, and targeted drug delivery can boost DNA repair drug research and development activities. Next-generation sequencing has enabled identification of genetic variants and mutations associated with various diseases. This has facilitated development of precision medicines that can specifically target DNA repair pathways. Furthermore, CRISPR-Cas9 gene editing tool is revolutionizing the creation of targeted DNA repair strategies. Continuous improvements in these techniques will aid discovery of novel drug targets and biomarkers. With reduction in genome sequencing costs, clinical integration of such omics data is widespread. This is positively impacting drug innovation and approval processes for DNA repair agents.
High cost of drug development can hamper the market growth
DNA repair drug development involves complex molecular research and clinical trial procedures, owing to the delicate nature of human genetic material. This makes the overall cost and time required for new drug approval an enormous investment. The average cost of developing a new molecular entity ranges between USD 2-3 billion. Furthermore, failure rates in clinical trials are also high due to safety and efficacy issues. This risk-high investment scenario discourages many small biotech companies and deters investors. Limited funding availability can hamper the market growth as most repair drugs are still in early R&D phases. Substantial capital is needed to transform pipeline candidates into marketed therapies.
Regulatory compliance issues hamper commercialization of new repair agents
There are several stringent regulations for approval and marketing of novel gene therapies, cell and tissue engineering products globally. DNA repair drugs involve direct manipulation of the human genome, hence, evoke safety and ethical concerns from regulatory authorities. Escalating oversight on aspects such as preclinical research methodologies, long-term safety data, and post-marketing surveillance presents compliance challenges. Any non-adherence to guidelines can lead to program delays or termination. Furthermore, complex patent landscape and intellectual property issues surround the development of precision repair therapeutics. Navigating the regulatory framework while upholding IP rights requires specialized expertise and compliance management systems which increase the commercialization costs.
Growing collaborations between industry and academia offer opportunities
Collaborative R&D models between pharmaceutical/biotech players and leading academic research institutes working in DNA repair fields can offer growth opportunities. Such collaborations allow sharing of clinical trial resources, multi-disciplinary expertise, and facilities to accelerate promising programs. For example, Novartis' collaboration with Dana-Farber Cancer Institute or Eli Lilly's partnership with Scripps Research. Large pharma firms are open to strategic licensing deals and co-development agreements related to early-stage repair therapies showing clinical proof of concept. This helps attract funding from private sources as well. Growing availability of multi-omics data repositories also aids discovery and validation of novel therapeutic targets through collaborative screening efforts. By combining their synergistic strengths, industry-academia alliances can enhance market opportunities.
Personalized medicine trend offers lucrative prospects
Focus on development of personalized or precision therapies with capabilities to correct patient-specific genetic anomalies driving their illnesses can offer growth opportunities. By leveraging pharmacogenomics and pharmacogenetics, DNA repair therapeutics can be customized as per individual's genomic profile and clinical response. This allows maximizing drug efficacy while mitigating adverse reactions. Ongoing R&D into genome editing with CRISPR, gene silencing RNAi technology, and cell/gene therapy modalities also enables pioneering of tailored repair solutions. Their superlative targeting ability resonates well with the growing demand for personalized care approaches worldwide.
Link: https://www.coherentmarketinsights.com/market-insight/dna-repair-drugs-market-2617
Key Development
- In June 2024, Merck provided updates on its oncology pipeline, emphasizing its focused approach to developing potential new medicines for cancer patients. It include plans to initiate multiple Phase Ib and II clinical studies for tuvusertib and M9466, both DNA damage response inhibitors. Merck has advanced its lead antibody-drug conjugate (ADC), M9140, to Phase Ib, following promising clinical results and intends to explore its application in additional cancer types.
- In December 2022, the European Union sanctioned the use of AstraZeneca and MSD's Lynparza (olaparib) alongside abiraterone and prednisone or prednisolone for treating metastatic castration-resistant prostate cancer (mCRPC) in adult males who are ineligible for chemotherapy
- In April 2022, Janssen Pharmaceutical submitted an application to the European Medicines Agency (EMA) seeking approval for niraparib in combination with abiraterone acetate, formulated as a dual-action tablet (DAT), along with prednisolone, for the treatment of patients with prostate cancer who have progressed to metastatic castration-resistant prostate cancer (mCRPC)
Key Players: AstraZeneca PLC, Merck & Co., Inc., Pfizer Inc., Clovis Oncology, Johnson & Johnson Services, Inc., Bayer AG, Bristol-Myers Squibb Company, Eli Lilly and Company, GlaxoSmithKline plc (GSK), Novartis AG, Roche Holding AG, Agios Pharmaceuticals, Inc., AbbVie Inc., Teva Pharmaceutical Industries Ltd., BioMarin Pharmaceutical Inc., Takeda Pharmaceutical Company Limited, NMS Group
