WILMS TUMOR PROTEIN MARKET ANALYSIS

Market News

Global Wilms Tumor Protein Market- Recent Developments

• Children’s Hospital Los Angeles uncover new clues to the origin of Wilms Tumor (2023):  On May 1, 2023, according to a study published by Advanced Science, scientists at the GOFARR Laboratory in Urology conducted a comparative analysis between kidney progenitor cells derived from a tumor and precursor cells obtained from a healthy kidney. Under normal circumstances, these precursor cells undergo maturation into functional kidney cells. However, when their early developmental processes are disrupted, these exhibit behavior reminiscent of cancer stem cells.
• A new study focusing the organoid-on-chip model targeting Wilms tumor (2023): On August 23, 2023, the research team at Wyss Institute at Harvard University study utilized an innovative model known as an immune-infiltrated human kidney organoid-on-chip. In this model, they showed that a T cell bispecific antibody (TCB) designed to target an antigen associated with the Wilms tumor-1 protein (WT1-TCB) has the unique capability of recruiting immune cells, notably cytotoxic T cells (depicted in green), to specific clusters of podocytes (depicted in blue). This recruitment ultimately results in the destruction of these podocytes.
• A new clinical phase 1 study evaluating CUE-102 (2022): In August 2022, the initial patient had received their first dose in a phase 1 dose escalation study registered under NCT05360680. This study is investigating CUE-102, a member of the interleukin 2 (IL-2) series, as a standalone treatment for individuals with recurrent or metastatic cancers that exhibit the presence of Wilms' Tumor 1 (WT1). According to an official press release from Cue Biopharma, a clinical-stage biopharmaceutical company, the research will specifically concentrate on colorectal, gastric, pancreatic, and ovarian cancers.

Acquisition and Partnerships

• Acquisition of Abcam plc by Danaher Corporation (2023): On August 28, 2023, Abcam plc, a global leader in the supply of life science research tools, announced that it had entered into a definitive agreement. As per agreement, Danaher Corporation will acquire all of the outstanding shares of Abcam for US$ 24.00 per share in cash.
• Acquisition of Olink Holding AB by Thermo Fisher Scientific Inc. (2023): On October 17, 2023, Thermo Fisher Scientific Inc., the global leader in supporting scientific endeavors, and Olink Holding AB, a prominent provider of cutting-edge proteomics solutions, jointly announced that their boards of directors had given the green light to Thermo Fisher's offer to purchase Olink at a price of US$ 26.00 for each common share in cash, equating to US$ 26.00 per American Depositary Share (ADS) in cash.
• Collaboration between ERS Genomics Limited and Santa Cruz Biotechnology Inc (2023): On August 10, 2023, ERS Genomics Limited, a global leader in providing access to foundational patents covering CRISPR/Cas9 intellectual property and licensing announced a new license agreement with Santa Cruz Biotechnology Inc., a developer of biological products for medical research. This agreement is non-exclusive and provides SCBT with access to the ERS CRISPR/Cas9 patent portfolio.
• Partnership between Bio-Techne Corporation and Cell Signaling Technology (2023): On February 14, 2023, Bio-Techne Corporation, a leading developer and manufacturer of high-quality purified proteins and reagent solutions and Cell Signaling Technology (CST), a privately held company that develops and produces medical reagents jointly announced the incorporation of Simple Western validation into CST antibodies. This enhancement offers researchers across various fields a more streamlined approach to investigating crucial molecular signaling pathways on a reliable and validated platform. The ability to obtain precise data swiftly and efficiently is essential for progress in drug discovery and development. This continued collaboration will enable an extended selection of Simple Western validated antibodies targeting various molecules in diverse disciplines.