U.S. ACELLULAR DERMAL MATRICES MARKET ANALYSIS

The U.S. acellular dermal matrices market is estimated to be valued at US$ 2.79 Bn in 2023 and is expected to exhibit a CAGR of 11% during the forecast period (2023-2030).

Analysts’ Views on the U.S. Acellular Dermal Matrices Market:

Increasing research and development (R&D) activities by the key market players is expected to drive the growth of the U.S. acellular dermal matrices market over the forecast period. For instance, in April 2022, Memorial Sloan Kettering Cancer Center, a cancer treatment and research institution based in New York, U.S., initiated a clinical trial titled “A Randomized Controlled Trial of Prepectoral Breast Reconstruction With and Without Acellular Dermal Matrix”. The study is currently in phase 3 which is estimated to get completed in March 2024.

Figure 1. U.S. Acellular Dermal Matrices Market Share (%), By Application, 2023

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U.S. Acellular Dermal Matrices Market - Drivers

• Increasing number of surgeries: Increasing number of surgeries performed is expected to drive the growth of the U.S. acellular dermal matrices market over the forecast period. For instance, on September 21, 2023, according to data published by Cleveland Clinic, more than 1 million hernia surgeries are performed in the U.S. annually.
• Increasing adoption of organic growth strategies such as product launch: Increasing adoption of organic growth strategies such as product launch by the key market players is expected to drive the growth of the U.S. acellular dermal matrices market over the forecast period. For instance, in November 2021, Sanara MedTech Inc., a provider of products and technologies for surgical and chronic wound care dedicated in improving patient outcomes, launched two new innovative extracellular matrix products named- FORTIFY TRGT and FORTIFY FLOWABLE. FORTIFY FLOWABLE Extracellular Matrix is an advanced wound care device that presents the SIS ECM technology in a way that can fill irregular wound shapes and depths.

Figure 2. U.S. Acellular Dermal Matrices Market Share (%), By Origin, 2023

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U.S. Acellular Dermal Matrices Market - Impact of Coronavirus (COVID-19) Pandemic

Since the COVID-19 virus outbreak in December 2019, the disease spread to over 100 countries across the globe, and the World Health Organization (WHO) declared it a public health emergency on January 30, 2020.

COVID-19 affected the economy in three main ways: by directly affecting the production and demand of drugs, by creating disruptions in distribution channels, and through its financial impact on firms and financial markets. It affected specialized medical services in unprecedented ways. Surgical decision making which is always regarded as the most important aspect of care undertook an added layer of complexity in the face of the COVID-19 pandemic. This pandemic placed a strain on healthcare systems and providers, as well as forcing difficult choices about whether care can and should be delayed or reprioritized. The need to dedicate major economic, infrastructural, and medical resources to the assistance of critically ill COVID-19 patients is causing a redistribution of the activities of several medical disciplines not primarily involved in the management of COVID-19 patients.

COVID-19 negatively impacted the U.S. acellular dermal matrices market as the pandemic placed a strain on the healthcare systems and providers, as well as forced difficult choices about whether care should be delayed or reprioritized. Many surgeries were delayed or canceled due to the pandemic, which affected the U.S acellular dermal matrices market negatively.

U.S. Acellular Dermal Matrices Market Segmentation:

U.S. acellular dermal matrices market is segmented into origin, application, place of setting, and region.

• By origin, the market is segmented into human dermis, porcine dermis, and bovine dermis. Out of which, the human dermis segment is expected to hold a dominant position in the U.S. acellular dermal matrices market during the forecast period. Human dermis is preferred by surgeons and patients as it minimizes the risk of rejection or allergic reaction. As the material is sourced from human tissue, it is less likely to trigger an immune response in the recipient's body compared to porcine or bovine tissues. This reduces complications and allows for faster healing times.
• By application, the market is segmented into [acute wounds (burns, trauma, cancers, and infections), chronic wounds (diabetic foot ulcers, venous leg ulcers, pressure ulcer, and others), and reconstruction procedures (abdominal wall procedures, breast procedures, orthopedic procedures, and others]. Out of which, the reconstruction procedures segment is expected to dominate the market over the forecast period, due to the increasing number of reconstruction procedures performed in the U.S. For instance, in October 2022, according to data published by Yale Medicine, in 2020, nearly 138,000 breast reconstructions were done in the U.S. among women who needed a mastectomy to either eliminate an active breast cancer or prevent it from occurring.
• By place of setting, the market is segmented into hospitals, ambulatory surgical centers, and office based. Out of which, the hospitals segment is expected to dominate the market over the forecast period, due to increasing adoption of organic growth strategies such as launch of new hospitals in the U.S. For instance, in January 2020, Hospital for Special Surgery, a medical center focused on musculoskeletal health, launched a new hospital in Florida, U.S.

U.S. Acellular Dermal Matrices Market: Key Developments

• In August 2021, Allosource, a company that manufactures fresh cartilage tissue for joint repair and skin allografts to heal severe burn, launched AlloMend Ultra-Thick Acellular Dermal Matrix (ADM). The product was designed for use in the repair or replacement of damaged or inadequate tissue required in demanding procedures, such as superior capsule reconstruction (SCR).
• In March 2022, Smith&Nephew, the global medical technology business, announced the publication of a peer-reviewed study in the Advances in Wound Care Journal, providing results for Medicare patients with diabetic foot ulcers (DFUs) demonstrating that, in comparison to leading cellular therapies, GRAFIX Cryopreserved Placental Membrane lowered DFU recurrence rates in half.
• On March 28, 2023, Bimini Health Tech, a global provider in the breast reconstruction and regenerative product and therapy announced that it acquired the exclusive rights of Acellular Dermal Matrix (“ADM”) technology for use in plastic and reconstructive surgery field. By acquiring the exclusive license for this technology, Bimini Health Tech will be able to leverage its existing infrastructure and expertise of the important technology to a wider patient population with an estimated U.S. market.

U.S. Acellular Dermal Matrices Market: Trends

Increasing adoption of inorganic growth strategies such as agreement: Increasing adoption of inorganic growth strategies, such as agreements, by the key market players is expected to drive the growth of the U.S acellular dermal matrices market over the forecast period. For instance, on March 22, 2023, Aziyo Biologics, Inc, a company that develops and commercializes biologic products to improve compatibility between medical devices and the patients who need them, and Sientra, Inc., a medical aesthetics company focusing on plastic surgery, announced that they have entered into an agreement to expand the distribution of Aziyo’s SimpliDerm product line. Under the agreement terms, Aziyo Biologics, Inc will grant Sientra, Inc., certain non-exclusive rights in the U.S. to market, sell, and distribute Aziyo’s SimpliDerm for selective use in reconstruction surgery. SimpliDerm is a pre-hydrated human acellular dermal matrix (hADM) that uses a proprietary process to preserve key growth factors of native dermis that supports faster integration and more rapid revascularization while demonstrating a lower risk of inflammatory response.

U.S. Acellular Dermal Matrices Market: Restraint

• Complications of acellular dermal matrices in breast surgery: Complications of acellular dermal matrices in breast surgery and plastic surgery are expected to hamper the growth of the U.S. acellular dermal matrices market. For instance, in December 2021, according to data published, by National Library of Medicine, seroma, infection, mastectomy skin necrosis, and expander/implant loss were the most commonly reported complications with acellular dermal matrices. The most common complication found was necrosis/impaired healing.
• Counterbalance: The key market players must focus in adopting launching of products which would not involve any sort of complications.

U.S. Acellular Dermal Matrices Market - Key Players

The major players operating in the U.S. acellular dermal matrices market includes Integra LifeSciences Corporation, AbbVie Inc., Johnson & Johnson, HansBioMed, Becton, Dickinson and Company, Cook Group, Smith & Nephew Plc., Reprise Biomedical, Organogenesis Holdings Inc., Tissue Regenix, LifeNet Health, Zimmer Biomet Holdings, Inc., Stryker Corporation, MiMedx Group, PolyNovo Limited, Fidia Pharma USA Inc., Baxter International Inc., In2Bones Global, and AlloSource.

Definition: Acellular dermal matrix (ADM) is a soft connective tissue graft generated by a decellularization process that preserves the intact extracellular skin matrix. Upon implantation, this structure serves as a scaffold for donor-side cells to facilitate subsequent incorporation and revascularization.