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North America has dominated the global treatment resistant depression market for many years and it continues to hold the largest share of 38.2% in 2024. This can mainly be attributed to factors such as high prevalence of mental disorders in the region, presence of favorable reimbursement policies for new drug approvals, and concentration of major industry players in the region. The U.S. alone accounts for over half of the regional market size owing to the large population suffering from depression and growing awareness. The developed healthcare infrastructure and high spending on specialty drugs have further assisted market growth.
Asia Pacific has lately emerged as the fastest growing regional market for treatment resistant depression. The rise of the Asian market can be credited to increasing mental health problems, growing investments by international brands, and improving accessibility of drugs. In particular, market expansion in India and China has been remarkable. This is because both countries represent huge patient pools and are strategically focusing on broader health insurance coverage for such treatments. Local manufacturers are additionally strengthening their presence by enhancing production capabilities and introducing low-cost generic alternatives. Moreover, participation from global pharmaceutical players is helping expand the available product portfolio and drive overall market uptake in Asia Pacific.
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