TRANSTHYRETIN AMYLOID CARDIOMYOPATHY TREATMENT MARKET ANALYSIS

Market News

Global Transthyretin Amyloid Cardiomyopathy (ATTR-CM) Treatment Market : Key Developments

• In September 2023, Alnylam Pharmaceuticals, a U.S.-based biopharmaceutical company, announced the positive outcome of the U.S. Food and Drug Administration’s (FDA) Cardiovascular and Renal Drugs Advisory Committee (CRDAC) meeting to discuss the supplemental New Drug Application (sNDA) for patisiran,  an investigational RNAi therapeutic in development for the treatment of the cardiomyopathy of transthyretin-mediated (ATTR) amyloidosis.
• In November 2022, Ionis Pharmaceuticals, Inc., a U.S.-based biotechnology company, initiated a phase 3 study in collaboration with AstraZeneca, a multinational pharmaceutical and biotechnology company, to assess the long-term safety of eplontersen (ION-682884) in patients with transthyretin-mediated amyloid cardiomyopathy (ATTR-CM).
• In December 2021, Pfizer Inc., a multinational pharmaceutical and biotechnology corporation, announced the publication of a post-hoc, interim analysis showing that treatment with VYNDAQEL (tafamidis meglumine) / VYNDAMAX (tafamidis) provided a clinically significant survival benefit at five years for patients with transthyretin amyloid cardiomyopathy (ATTR-CM).

Another key trend includes increasing adoption of inorganic growth strategies by key market players: Increasing adoption of inorganic growth strategies such as acquisition and merger by the key market players is a prominent trend in the market.  For instance, in July 2021, Eidos Therapeutics, a clinical-stage biotech company, was acquired by BridgeBio Pharma, a commercial-stage biopharmaceutical company. This acquisition accelerated BridgeBio's development of its investigational therapy for the treatment of ATTR-CM, AG10. The acquisition expanded BridgeBio's pipeline of therapies for rare and other diseases