Significant healthcare burden due to short bowel syndrome, especially in low-income countries
According to Crohn’s & Colitis Foundation of America, in 2010 there were 10,000–20,000 people in the reported cases of short bowel syndrome, out of which 25% people suffer some or the other complication within two years of contracting the condition. The rate of absorption decreases and due to lack of sufficient nutrients to the body, many children die due to malnutrition. According to Sancilio and Company, Inc, most cases of short bowel syndrome are due to birth in congenital anomaly, in which there occurs a rotation of midgut and the child dies before the age of 6 years. According to Nutrinia Ltd, the existing approach to treat infants suffering from short bowel syndrome includes proper nutritional, pharmacologic, and surgical interventions. The objective is to endorse enteral nutrition, while curtailing the difficulties of parenteral nutrition therapy. Most of the patients are given long-term parenteral treatment, which affects the patient and significantly increases the chances of liver disease, infections, and other complications. Babies who have substantial short bowel syndrome frequently struggle from intestinal failure-associated liver disease, bloodstream infections, and bacterial overgrowth. Furthermore, parenteral nutrition leads to a substantial economic burden on the general population and the healthcare system, with overall annual costs ranging from an estimated US$ 180,000 to US$ 570,000 and more.
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