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Increasing R&D investments by key players
Top pharmaceutical players have recognized the commercial potential in developing innovative therapeutics for psoriatic arthritis due to its large underserved patient base across global markets. Massive R&D spending in recent years on target pathway drug development specifically for PsA has generated positive clinical outcomes. Successful approval and uptake of novel biologics has validated the need for more effective treatment alternatives beyond traditional disease-modifying anti-rheumatic drugs (DMARDs).
Complex molecular pathways associated with chronic inflammation in PsA present multiple lucrative therapeutic targets. Advance research on genes, biomarkers and immunological mechanisms driving PsA pathogenesis have opened up new directions for precision therapies. Companies are exploring monoclonal antibodies, small molecule inhibitors and cell/gene therapies focused on specific targets involved in immune system dysregulation and cytokine signaling linked to PsA. First-in-class new chemical entities achieving superior efficacy with better safety profiles than existing drugs offer a competitive strategic advantage and market exclusivity.
Several big pharma companies have set up dedicated research divisions and global clinical trial networks to expedite development while accessing diverse patient pools. Higher R&D budgets and strategic collaborations allow testing diverse treatment paradigms for better disease modification and functional restoration in joints. First-mover products entering a space deficient in solutions could corner a major share of the PsA market in the long run.
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