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North America has established itself as the dominant regional market for proton pump inhibitors globally with an estimated market share of 38.3 % in 2024. The regional market growth can be attributed to favourable reimbursement policies and higher healthcare spending in the U.S. and Canada. Major pharmaceutical companies have their origins and headquarters in the region, facilitating high R&D investments and strong product pipelines. There is a significant presence of industry leaders like Pfizer and AstraZeneca that enjoy brand loyalty for their established products. Moreover, the region promotes medical awareness and adoption of preventive healthcare measures for gastric issues like ulcers. This has enabled proton pump inhibitors to become a mainstream therapy choice. However, pricing pressures from generics and competitive brands may challenge future growth prospects for innovator products in North America.
Asia Pacific region has emerged as the fastest growing market for proton pump inhibitors worldwide. Rapidly increasing healthcare expenditures, rising obesity due to changing lifestyles and diet habits have boosted demand for acid-reducing drugs. Countries like India, China and Japan have a large patient pool suffering from gastric ailments, owing to their aging populations and hereditary risks. Local companies in these markets have strengthened their presence through cost-effective generic versions. International brands are also targeting this region through product licensing, joint ventures and imports. However, lack of stringent regulations and enforcement has promoted proliferation of poor quality copies. This poses a significant threat to established innovators while benefiting local unorganized players.
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