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Technological advancements in proteomics tools
Remarkable strides in systems biology approaches and omics technologies have transformed the field of proteomics in recent years. More powerful mass-spectrometers, microfluidics-based devices, high resolution microscopy tools and automated assay platforms have enhanced capabilities for comprehensive and in-depth protein analysis. Researchers can now analyze proteomes with greater accuracy, speed, resolution and throughput. Advancements such as single-cell proteomics, spatial proteomics, and quantitative standard-free proteomics are improving knowledge of molecular phenotypes. This widens scope and scale of proteomics studies. Growing sophistication of proteomics tools can offer new opportunities for development of synergistic multi-omics workflows. Integrating functional outputs of genomics and transcriptomics with insights from proteomics is key for building predictive models of cellular systems. Companies recognize the need for protein assays that can analyze thousands of samples not just from tissue lysates but other specimen types. Assays compatible with imaging mass-spectrometry are an example meeting this demand. Tools enabling characterization of protein isoforms and PTMswithin the same workflow boost statistical power of clinical studies. This transforms requirements for assays in terms of performance, scope and automation. Advancements like microfluidic chips, proximity extension assays and bead/array based assays improve precision, throughput and reduce sample volume needs. Newer assays require just picograms of protein for accurate quantification.
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