Increasing cost of anticancer drugs is expected to be a major factor hampering growth of the market. For instance, in June 2017, The Scottish Medicines Consortium (SMC) denied access to pertuzumab in England, which was available via the Cancer Drugs Fund (CDF) in Europe. The drug was rejected by SMC as the treatment of HER2 positive breast cancer was not cost effective when pertuzumab was used in combination with trastuzumab and docetaxel.
Moreover, according to a study published in the journal Oncology, September 2015, although the use of pertuzumab with docetaxel and trastuzumab as first-line therapy for HER2 positive breast cancer has been shown to yield a substantial survival benefit, the therapy is not cost effective in the U.S. Also, according to the same source, the cost of treating HER2 positive breast cancer with pertuzumab and other drugs is US$ 509,845 and that with only docetaxel and trastuzumab is US$ 135,092.
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