Furthermore, to cater to increasing demand for vaccines, manufacturers are also involved in mergers and acquisitions and new product launches in the peptide cancer vaccine market. For instance, in May 2018, Merck & Co. invested US$ 125 Million in Moderna Therapeutics. This expansion included partnering on mRNA-5671, Moderna’s mRNA KRAS cancer vaccine, and other shared antigen mRNA cancer vaccines. This vaccine includes an mRNA for four most commonly found KRAS mutations, which according to Moderna will cover most of the mutation that occur in non-small-cell lung cancer (NSCLC), colorectal cancer, and pancreatic cancer. In November 2017, Moderna launched the Phase I KEYNOTE-603 study of mRNA-4157, an mRNA-based personalized cancer vaccine being developed with Merck & Co., through a US$ 100-million-plus mRNA partnership.
Furthermore, in November 2017, TapImmune Inc., a clinical-stage immune-oncology company with ongoing clinical trials in breast and ovarian cancer, announced that the company has enrolled the final patient in randomized Phase 2 clinical study for its novel T-cell vaccine candidate TPIV200 for the treatment of triple-negative breast cancer (TNBC). More such clinical trials for peptide cancer vaccines are expected to boost growth of the global peptide cancer vaccine market over the forecast period.
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