NISIN MARKET ANALYSIS

The nisin Market size is valued at US$ 389 Mn in 2024 and is expected to reach US$ 533.3 Mn by 2031, growing at a compound annual growth rate (CAGR) of 4.6% from 2024 to 2031.

Global Nisin Market Regional Insights:

• North America is expected to be the largest market for global nisin market, which is expected to grow at a CAGR of over 39% during the forecast period. The growth of this market in North America is due to increasing demand for nisin in countries such as U.S., and Canada.
• Asia Pacific is expected to be the second-largest market for global nisin market, which is expected to grow at a CAGR of over 28% during the forecast period. The growth of this market in Asia Pacific is due to increasing demand for nisin in countries such as India and China.
• Europe is expected to be the fastest-growing market for global nisin market, which is expected to grow at a CAGR of over 18% during the forecast period. The growth of this market in Europe is due to increasing demand for nisin in countries such as France, Germany, the Netherlands, and Russia.

Figure 1. Nisin Market Share (%), By Region, 2024

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Analyst’s Views:

Global nisin market is expected to experience steady growth in the near future. As a natural preservative, the demand for nisin is increasing from the food and beverages industry due to rising health-consciousness among consumers. The ability of nisin to inhibit harmful bacteria like listeria makes it suitable for use in processed meat and dairy products. The Asia Pacific region, led by China and India, offers lucrative opportunities for nisin companies owing to rising meat consumption in this region.

While the natural source-based production of nisin is a major driver, high production costs remain a challenge. Alternatively, companies are exploring more cost-effective fermentation-based production methods to improve margins. Stringent regulatory approval process could slow down industry expansion into new application areas like pharmaceuticals and cosmetics. However, obtaining Generally recognized as safe status in major markets will accelerate commercialization opportunities.

Food safety regulations are also becoming more stringent globally, thereby benefiting nisin suppliers. The growing demand for clean-label and organic preservatives presents opportunities for industry participants to leverage natural properties of nisin. Leading European nations like Germany, U.K., and France contribute significantly to the revenues. North America witnesses high demand from packaged food producers while emerging countries offer promising opportunities.

Global Nisin Market Drivers:

Rising demand for natural preservatives: The demand for natural preservatives is growing significantly in the global food industry which is positively impacting the growth of the market. Nisin being a natural preservative extracted from lactococcus lactis bacteria, it is gaining widespread acceptance amongst food manufacturers and consumers. More and more people prefer food products with natural ingredients over chemical preservatives due to rising health consciousness.

Nisin is an effective natural antimicrobial agent that helps in extending the shelf life of various food products without compromising on quality and taste. It is especially effective against various harmful bacteria like listeria monocytogenes and staphylococcus aureus. The International Agency for Research on Cancer has also classified Nisin as a possible carcinogen in contrast to commonly used chemical preservatives which are known carcinogens. With growing preference for clean label products free from artificial ingredients and preservatives, the demand for all-natural preservatives like Nisin is surging across different food applications worldwide.

Growth of processed food industry: The growth of the processed food industry has led to rise in demand for preservatives like nisin, driving the market. With rapid urbanization and changing lifestyles, consumption of packaged, eady-to-eat and prepared foods has increased tremendously. However, processing and packaging of foods opens multiple avenues for microbial contamination, which can spoil foods and threaten public health.

To curb spoilage and extend shelf-life of processed foods, use of food preservatives has become imperative. Nisin, a bacteriocin produced by lactococcus lactis bacteria, has emerged as one of the most effective and naturally-derived preservative. As a polypeptide antibiotic, nisin inhibits pathogenesis of various food-borne pathogens like listeria monocytogenes and inhibits growth of spoilage microorganisms.

Global Nisin Market Opportunities:

Innovation of new product formulations: Innovation of new product formulations presents a significant opportunity for growth in the market. Nisin is a bacteriocin that is produced by some strains of Lactococcus lactis that is used as a natural food preservative. It has applications across meat, dairy, beverages and other food industries to inhibit spoilage and prevent pathogenic bacteria growth.

Developing new formulation methods can help address some of the existing limitations with nisin and unlock its potential in more product categories. The heat stability of nisin is a concern for applications involving higher processing temperatures. Research into novel encapsulation and microencapsulation techniques could resolve this issue and allow nisin to be utilized more widely in sterilized foods and canned goods. New inert carrier materials that are heat resistant yet safely release nisin under ideal conditions in the product could vastly expand the market.

Another avenue is discovering synergistic combinations of nisin with other. Generally Recognized as Safe compounds through formulation science. Certain plant extracts, essential oils and bacteriocins from other microbes have exhibited synergistic activity when combined with nisin. Optimized blends incorporating such ingredients formulated for specific food matrices, along with minimum inhibitory concentration testing, could deliver highly effective and natural preservative systems. This paves the way for nisin to be adopted as a “clean label” solution in more processed snacks, bakery, and confectionery products.

Growing demand for processed and packaged food: Growing demand for processed and packaged food is indeed presenting a huge opportunity for this market. With changing lifestyles and busier schedules, more people rely on ready-to-eat meals and packaged snacks for their daily nutrition intake. However, processed foods are also more prone to bacterial contamination which can severely impact the health of consumers. This is where nisin, a natural food preservative, plays a vital role in ensuring the safety of packaged foods.

As an antimicrobial peptide produced by lactococcus lactis, nisin is considered very effective in inhibiting the growth of gram-positive pathogenic and spoilage bacteria. It is approved for use as a food preservative across many countries and found widely in processed meat, dairy products, canned foods, and others. With rising consumption of packaged foods worldwide, the need for reliable and natural food preservatives like nisin to extend shelf-life without compromising on quality and nutrition has increased tremendously.

Global Nisin Market Trends:

Increasing demand for clean label and organic foods: Increasing demand for clean label and organic foods among health-conscious consumers has significantly influenced this market in 2022. Consumers are increasingly seeking out products with simple, natural ingredients without artificial preservatives, colours, or flavors. This shift towards clean label products is driven by growing consumer awareness about the link between diet and health, and the desire to avoid synthetic and chemically-modified ingredients.

Nisin, a food preservative derived from milk, is viewed as a clean label and natural alternative to chemical preservatives. It has found widespread applications in various food products like dairy, meat, beverages and canned foods to inhibit the growth of harmful bacteria and extend shelf life. As clean label trends continue gaining momentum, manufacturers are responding by reformulating their products and removing artificial preservatives in favour of natural agents like nisin. According to the Non- genetically modified organism Project report, in 2022, over 70% of U.S. consumers read product labels to avoid artificial preservatives and this figure is growing each year, thus reflecting increased scepticism about synthetically produced food additives. This has significantly boosted demand for clean label preservatives like nisin.

Growing adoption of natural preservatives over chemical preservatives: The growing consumer preference for natural and organic products over chemical ones has been positively influencing this market. Consumers are more health conscious and seek food and beverage products with simple, recognizable ingredients lists that do not contain harsh chemical preservatives. This trend has been driving increased demand for all-natural preservatives like nisin.

Nisin is a natural preservative produced by some strains of Lactococcus lactis bacteria during milk fermentation. It is a bacteriocin that inhibits growth of pathogenic and spoilage microorganisms. Several studies have demonstrated nisin to be effective against bacteria such as listeria monocytogenes and clostridium botulinum. Compared to traditional chemical preservatives, it offers superior effectiveness and all-natural processing attributes without compromising on food safety. Food manufacturers have been increasingly incorporating Nisin into products like dairy, meat, beverages and baked goods as a 'clean label' ingredient.

Global Nisin Market Restraints:

Availability of substitute products: Global nisin market is facing restraints in its growth trajectory due to the presence of alternative natural preservative options available to the food processing industry. Nisin is a natural food preservative primarily that are used for dairy products, meat and other protein-based foods to increase their shelf life by preventing the growth of bacteria. However, there are several plant-based and mineral-based preservatives that serve as viable substitutes. For example, potassium sorbate and sodium benzoate are widely used synthetic preservatives with antimicrobial properties similar to Nisin. They are often preferred by many commercial food manufacturers due to their low cost and ease of application in different food types.

Moreover, traditional preservative methods such as drying, salting, and smoking are still popular in several emerging market regions of Asia Pacific and Middle East & Africa. According to the UN Food and Agriculture Organization database, in 2020, around 30% of meat produced globally is traditionally preserved before consumption mainly in developing countries. This significantly curtails the market for newer food preservatives in the short to medium term. Natural plant extracts from rosemary, oregano and thyme that contain antioxidant and antimicrobial compounds are also regaining popularity as clean label preservatives. Their acceptance by health-conscious consumers in developed markets such as North America and Europe poses a challenge to the growth of nisin.

High production cost of nisin: The high production cost of nisin is a major factor restraining the growth of this market. Nisin is produced through fermentation of dairy by-products like whey by specific strains of lactococcus lactis bacteria. The fermentation process to produce nisin is complex and lengthy, taking around 5-7 days for the bacteria to multiply and secrete nisin into the growth medium. This makes the production process highly resource and time intensive.

The fermentation requires careful maintenance of temperature, potential of hydrogen levels and aseptic conditions throughout the process. Even minor deviations can reduce nisin yields or compromise its quality. This translates to higher capital and operating costs for production plants. Strict quality control during downstream processing like purification and formulation is also needed to extract highly purified nisin suitable for use in food applications. All these factors contribute to the overall cost of production.

Counterbalance: To overcome this restraint, the key market players need to follow strict quality control during downstream processing like purification, and formulation is also needed to extract highly purified nisin suitable for use in food applications, which might increase the global nisin growth in the market.

Recent Developments:

New Product launches:

• In January 2022, DSM launched a new integrated Food & Beverage business group to provide a full range of taste, texture, and health solutions to several end users. DSM is a global science-based company active in health, nutrition, and materials.
• In January 2021, DuPont Nutrition & Biosciences launched NovaGARD NR 100-G, a synergistic blend of two natural ingredients i.e., nisin and rosemary, in the Middle East and Africa. The new antimicrobial and antioxidant solution is effective against gram-positive bacteria and spores and therefore will help end users to protect the quality of their products. DuPont Nutrition & Biosciences is a global science-based company that provides innovative solutions in the areas of health, nutrition, and materials. The company offers a wide range of products and services, including food ingredients, enzymes, cultures, probiotics, and animal nutrition.

Figure 2. Nisin Market Share (%), By Application, 2024

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Top Companies in the Global Nisin Market

• Danisco A/S
• Amtech Biotech Co., Ltd
• Chihon Biotechnology Co., Ltd.
• Cayman Chemical
• Royal DSM N.V.
• Galactic
• Handary S.A.
• Sivelee B.V.
• Shandong Freda Biotechnology Co.
• Zhejiang Silver-Elephant Bio-engineering Co. Ltd.

Definition: The Nisin is a polycyclic antibacterial peptide that is produced by the bacterium lactococcus lactis that is used as a food preservative. It has 34 amino acid residues, including the uncommon amino acids lanthionine, methyllanthionine, didehydroalanine, and didehydroaminobutyric acid.