NEXT GENERATION PROBIOTICS MARKET ANALYSIS

The recent development in metaomics applications has extended the understanding of the human gut microbiota and its role in health and diseases. This increases the interest in using commensal bacteria as next-generation probiotic (NGP) for the prevention and treatment of disease as a novel health promoting approach. Next generation probiotics can develop either dietary supplement or novel drug that faces a new challenge in their efficacy, safety, technological robustness, and regulatory framework. Next generation probiotics to use as bio therapeutics must go through three rounds of clinical trials such as preclinical, toxicological studies and pharmacodynamics.

Global next generation probiotics market is estimated to be valued at US$ 168.1 million in 2022 and is expected to exhibit a CAGR of 11.2% during the forecast period (2022-2030).

Figure 1.Global Next Generation Probiotics Market Share (%), by Bacterial Candidate, 2022

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Global Next Generation Probiotics Market- Drivers

Increasing product launches by key players in market are expected to drive market growth over the forecast period. For instance, in June 2021, FitBiomics, a sports biotechnology company, launched its first consumer product under Nella Brand, a next-generation probiotics supplement for gut health in active adults uniquely sourced from the microbiome of elite athletes.

Moreover, in September 2020, Lonza, a leading global provider of integrated healthcare solutions, announced the launch of its L. plantarum (TWK10) ingredient, which is originally isolated from fermented vegetables, specifically Taiwanese Kimchi. The unique patented TWK10 strain is the next generation of probiotics. It is also a novel probiotic designed to deliver sports nutrition benefits for both elite athletes and active consumers. The TWK10 brand is clinically shown to enhance endurance and improve body composition and energy levels.

Figure 2.Global Next Generation Probiotics Market Share (%), by Region, 2022

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Global Next Generation Probiotics Market– Impact of Coronavirus (COVID-19) Pandemic

The supply of raw materials required for production of next generation probiotics has been severely disrupted due to the forced quarantine and lack of labor during the COVID-19 pandemic. As the link between regional warehouses is not smooth, transportation of raw materials between regions cannot be carried out successfully. This shortage of raw materials and components have negatively affected the supply chain of the next generation probiotics market. Thus, COVID-19 pandemic is expected to have negative impact on supply chain of next generation probiotics market.

According to an article published by the Exploratory Research in Clinical and Social Pharmacy Journal  is a peer reviewed, open access journal,  in June 2021, a study was carried out to evaluate the impact of COVID-19 on pharmaceutical systems and supply chain in  resource-limited countries in Sub-Saharan countries such as Namibia. This study revealed negative impact on availability and access of essential drugs, sanitation and hygiene products, and antimicrobials. Most pharmaceutical companies and pharmacies in Namibia experienced delayed manufacturing and distribution of drugs, which is attributed to reduced inter-country transportation of pharmaceutical goods and limited in-country capacity to manufacture drugs.

Moreover, according to data published by Multidisciplinary Digital Publishing Institute, a publisher of open access scientific journals, in April 2021, at this time of the COVID-19 pandemic, when no pharmacological strategies for prevention or treatment are available, attention to alternative therapies using probiotics must be considered. Emerging data suggest that changes in the immune homeostasis, induced by SARS CoV-2, might be mediated by gut microbiota. Elderly people have less diverse intestinal flora in which beneficial microorganisms deteriorate. This is in line with the observation that older individuals are more susceptible to SARS CoV-2 and more severe COVID-19. The administration of these NGPs, isolated from the human gut, could restore the microbiota and improve the immunity in the lungs. Indeed, several studies have suggested a connection between the gut and the lungs.

Global Next Generation Probiotics Market: Key Developments

On August 29, 2022, BioGaia, a biotechnology company, developed probiotic products and expanded its product portfolio with new bacterial strains, developed together with its owned subsidiary MetaboGen AB, a biotechnology research company. MetaboGen built a pilot plant in Eslöv, Sweden. The facility handles manufacturing of bacteria with different requirements during fermentation, both traditional lactobacilli as well as new which are extremely oxygen-sensitive strains.

On July 08 2022, A-Mansia Biotech, a privately held biotechnology company, revealed its new brand name along with plans to launch food supplement Akkermansia Muciniphila. The new brand name of A-Mansia Biotech is The Akkermansia Company.

Global Next Generation Probiotics Market: Restraint

Difficulties associated with the production of next-generation probiotics is expected to hinder the growth of the global next generation probiotics market. For instance, according to an article published by Network of Aquaculture Centres in Asia Pacific, an intergovernmental organization that promotes rural development through sustainable aquaculture and aquatic resources management, in 2021, NGP falls under the category of LBPs (live biotherapeutics) or drugs. Any probiotic strain that will be used as NGP is subject to the usual pharmaceutical clinical trials and research on its pharmacokinetics, pharmacodynamics, safety, and delivery routes. This process is stringent and poses significant hurdles on the pathway of NGP development and commercialization.

Global Next Generation Probiotics Market- Key Players

Major players operating in the global next generation probiotics market include Pendulum, Amsterdam Winclove Probiotics, Metabogen AB (Biogaia), Exeliom Biosciences, TargEDys, Chr. Hansen Holding A/S, YSOPIA Bioscience, A-Mansia Biotech, Next Gen Probiotics, Evolve Biosystems, and DuPont de Nemours, Inc.