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Technological advancements in molecular diagnostics
The molecular diagnostics market has witnessed significant technological innovation which has expanded its applications manifolds. Next generation sequencing or NGS has revolutionized genomic analysis, allowing fast and comprehensive profiling of the entire DNA or RNA composition from a simple sample. With continuously declining costs, whole genome sequencing is being utilized for diagnostic discovery research and shifting early disease detection capabilities. Synthetic biology is enabling design of novel biomarker detection platforms. Advanced machine learning algorithms are also being deployed to analyze the voluminous data generated from these sequencing tests and simplify reporting for clinicians. All these cutting-edge innovations have made molecular analysis more powerful, convenient and affordable. Miniaturization of molecular diagnostic devices using microfluidics and nanotechnology has enhanced portability. Miniaturized PCR and genome sequencing panels integrated on a single microchip or cartridge are simplifying testing. Examples include handheld and portable genetic analyzers and mini-labs which can perform complex multistep molecular assays on location, delivering results within hours instead of days. This has important applications in decentralized healthcare settings, especially for infectious disease control in developing regions. Transition to automation is further improving productivity, reducing manual errors, and turnaround times. Integration of molecular diagnostics onto smartphones is also being extensively researched for creating truly point-of-care testing solutions.
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