JANUS KINASE INHIBITOR MARKET ANALYSIS

Janus Kinase Inhibitor MarketSize and Trends

Jak inhibitors are increasingly preferred for industrial research due to their critical role in immune response signaling. For instance, in June 2018, Eli Lilly and Company announced approval from the U.S. Food and Drug Administration (FDA) for OLUMIANT (baricitinib) — an oral medication for rheumatoid arthritis in adults. Approval was granted for use of baricitinib in combination with methotrexate (MTX) or other disease-modifying antirheumatic drugs (DMARDs) or as monotherapy. The drug inhibits activation of Jak1/2 (Janus kinase 1 and 2) and decreases the production of inflammatory cytokines, thereby inhibiting inflammatory response. Therefore, increasing launch of new drugs is expected to fuel the global janus kinase inhibitor market growth over the forecast period.

Psoriatic arthritis is a form of arthritis, which is characterized by red patches of skin with silvery scales. Tofacitinib is a janus kinase inhibitor, which modulates cytokines that are required for signaling of inflammatory and immune response. Inclusion of new treatment options is expected to boost the global janus kinase inhibitor market growth over the forecast period. For instance, in December 2017, Pfizer Inc. received approval from the U.S. FDA for XELJANZ (TOFACITINIB) for treatment of adult patients suffering from psoriatic arthritis (PsA).

Furthermore, key manufacturers and research organizations are focused in research and development of new janus kinase inhibitor drugs. For instance, M.D. Anderson Cancer Center, in collaboration with Incyte Corporation, conducted phase -2 clinical trials (study completed in March 2017) to check effect of ruxolitinib in controlling advanced hematological malignancies.  Ruxolitinib is an inhibitor of Jak 1 and Jak2 kinases and arrests growth of transformed cells. Therefore, active research and development of new janus kinase inhibitor drugs is expected to fuel the global janus kinase inhibitor market growth over the forecast period.