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Combination therapies opening new avenuesAnother important driver is the encouraging results seen with combining different immunotherapy drugs or combining immunotherapy with other treatment modalities. Early successes with checkpoint inhibitors led to focus on their potential to work even better when paired together or added to conventional therapies. Ongoing research is exploring diverse combination regimens tailored to individual cancer types and stages of disease. Some combinations show response rates much higher than any drug alone. These are also helping widen the pool of patients who can benefit. For instance, combining a PD-1 inhibitor with CTLA-4 antibody is giving durable responses in melanoma, lung and other cancers. Adding these to chemotherapy prior to surgery in early breast cancer patients improves pathologic response rates. Similarly, providing immunotherapy before or after radiation helps recruit immune cells to target radiation boosted tumor cells or residuals. The scope is also extending to accelerator drugs that can enhance effects of PD-1/PDL-1 inhibitors when given together.
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