HYDROXYAPATITE MARKET ANALYSIS

The global hydroxyapatite market size was valued at US$ 2,250.19 million in 2022 and is anticipated to witness a compound annual growth rate (CAGR) of 6.52% from 2023 to 2030. The global hydroxyapatite market is projected to witness significant growth, due to increasing demand for orthopedic implants, dental care, and plastic surgery. The market growth is also attributed to increased demand for medical implants, rapid industrialization and urbanization, increase in consumer awareness, and surge in interest as a biomaterial for use in prosthetic applications.

Global Hydroxyapatite Market: Regional Insights

Regionally, North America is expected to dominate the global hydroxyapatite market during the forecast period. The presence of several key players in this region is anticipated to aid the market growth. In addition, the increase in investment and better healthcare infrastructure are also expected to support growth of the hydroxyapatite market in this region during the forecast period. Also, growing number of plastic surgery in the region is again propelling regional market growth. As per the report published by ISAPS in 2020, the country had around 269,514 Breast Augmentation, 242,259 Liposuction, 131,652 Abdominoplasty, 121,302 Breast Lift, and 113,988 Eyelid Surgery.

Asia Pacific region is anticipated to exhibit a significant growth in the hydroxyapatite market due to the increasing demand for dental care and plastic surgeries. Additionally, the growing elderly population in this region is predicted to improve the bone-related abnormalities and increase the overall demand for hydroxyapatite. Moreover, the government has encouraged the use of hydroxyapatite-based dental care products to reduce the risk of dental diseases and improve the oral hygiene of people due to increasing prevalence of dental problems. According to the National Bureau of Statistics of China, in 2019, patients in China received approximately 3.1 million dental implants, showing a growing trend in recent years. It was estimated that over 600 million people in China were suffering from dental problems, yet the diagnosis and treatment rates remained low.

Figure 1. Global Hydroxyapatite Market, By Region, 2022

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Global Hydroxyapatite Market Drivers:

Growing demand from prosthetic applications is fostering market growth

Hydroxyapatite is widely used in biomedical applications to coat/form prostheses or implants and as a filling material. Also, increasing healthcare expenditure across developed countries is propelling market growth. According to the journal published by the University of Toronto, Canada spends approximately 11.1% of its GDP on healthcare compared to other high-income countries. The government primarily funds the Canadian healthcare system, with only 30% from the private sector. Health expenditure in Germany in 2021 was EUR 465,707 million.

Increasing demand from orthopedic application is augmenting market growth

Orthopedic implants are used to support a broken or missing bone or joint. Growing prevalence of arthritis, osteoporosis, and other joints related products is also creating demand for orthopedic devices. According to a recent analysis of the Global Burden of Disease (GBD) data, approximately 1.71 billion people worldwide have musculoskeletal conditions. Osteoarthritis, rheumatoid arthritis, psoriatic arthritis, osteoporosis, osteopenia, and other joint conditions are included in musculoskeletal conditions.

Global Hydroxyapatite Market Opportunities:

Advent of hydroxyapatite ceramics is expected to offer potential market opportunities.  For instance, in September 2018, Bio-Rad Laboratories, Inc., a global marketer of life science research and clinical diagnostic products, announced the launch of two new chromatography media for process protein purification: CHT Ceramic Hydroxyapatite XT Media and Nuvia HP-Q Resin.

Increase in consumer awareness, and surge in interest as a biomaterial for use in prosthetic applications are expected to present significant growth opportunities. Moreover, growing popularity of micro-sized hydroxyapatite is again escalating market growth.

Global Hydroxyapatite Market Trends:

Hydroxyapatite is gaining popularity as an additive for dental products

Hydroxyapatite has become a popular additive to dental products. It can remineralize and strengthen teeth, increase fluoride absorption and help prevent cavities. It can also be used in bone grafting procedures to fill bone voids or defects.  The benefits of hydroxyapatite include its ability to stimulate bone growth, its osteoinductive properties and the fact that it is nontoxic and biocompatible.

Synthetic nanocrystalline hydroxyapatite is a growing trend

Synthetic nanocrystalline hydroxyapatite has been shown to have beneficial effects in the restoration and maintenance of tooth enamel. It remineralizes enamel and helps to fight bacteria, while being gentle on the enamel. It is available in a variety of formulations, including toothpastes, mouthwashes, gums, and chewing surfaces. It can also be used as a fertilizer to improve soil quality and water retention. It can be fabricated into nanoparticles or pellets and is slowly released into the soil for long periods of time.

Global Hydroxyapatite Market Restraints:

Poor mechanical properties hydroxyapatite

One of the major challenges faced by the hydroxyapatite market is the poor mechanical properties of this material, which limits its load-bearing capabilities.

High cost of implants

For instance, in India, a single implant with its prosthesis (cap/crown) would cost between 20,000- 50,000 INR, depending on the type and brand of the dental implant used. A bridge would cost between 9,000 and 30,000, depending on the material used (PFM/Zirconia/Emax). Such high cost of implants is expected to restrict its adoption in healthcare sector, thereby hindering market growth.

Figure 2. Global Hydroxyapatite Market, By Type, 2022

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Global Hydroxyapatite Market Segmentation:

The global hydroxyapatite market report is segmented into type, application, and geography

Based on type, the market is segmented into nano-sized, micro-sized, and greater than micrometers. Out of which, nano-sized is expected to dominate the global market over the forecast period and this is attributed to the growing application in bones and teeth enamel due to its properties, such as  bioactivity, biocompatibility, osteoconductivity, non-toxicity, and non- inflammatory nature.

Micro-sized segment is also expected to witness significant growth in the near future and this is owing to the growing demand from tissue engineering, drug and gene delivery, orthopedic and dental implant coating, and endodontic treatment like pulp capping.         

Based on application, the market is segmented into dental care, plastic surgery, orthopedic, and other applications (including non- medical applications). Out of which, dental care is expected to dominate the global market over the forecast period and this is attributed to its biocompatible property. Moreover, it is bioactive and non-toxic ceramic that has a close analogy to the inorganic portion of human bone and teeth.

Orthopedic segment is also expected to witness significant growth in the near future. It is the most commonly used bioactive ceramic material in scaffold for bone growth, bone tissue engineering, and bone void fillers for spine surgery and orthopedic.

Global Hydroxyapatite Market: Key Developments

In March 2022, Cgbio signed a five-year contract worth KRW 10 billion with Kerunxi Medical, a Chinese company specializing in dental equipment, for the export of Bongros Dental, a bone graft material.

In March 2022, The Cgbio signed an export contract with Shanghai Sanyou Medical for KRW 100 billion worth of bone substitute “BONGROS” for five years.

In April 2021, FLUIDINOVA   started   an   R&D   project, “FLUIDINOVA - Innovation in Nanocrystalline Hydroxyapatite Offering Synthetics and Industrial/ Organizational Processes.” With this project, the company expands the offer of new products for the pharmaceutical, medical devices, and 3D printing segment.

In January 2021, FLUIDINOVA started a project with INKplant, namely Ink- based Hybrid Multi-material Fabrication of Next Generation Implants. This project will develop an advanced 'toolbox' of technologies to enable 3D printing of tailor-made and is likely to enhance the company’s hydroxyapatite business.

Global Hydroxyapatite Market: Key Companies Insights

The global hydroxyapatite market is highly competitive. This is attributed to continuous launch of new technologies due to ongoing R &D and efforts by value chain participants. Moreover, key players are adopting various business growth strategies in order to expand their presence on regional as well as global basis. Some of the key players in the global hydroxyapatite market are APS Materials Inc., Berkeley Advanced Biomaterials (GNI Group Ltd), Bio-Rad Laboratories Inc., CGbio, FLUIDINOVA, Granulab Sdn. Bhd. (KPower Berhad), HOYA Technosurgical Corporation (HOYA Corporation), SANGI CO. LTD, SigmaGraft Biomaterials, Taihei Chemical Industrial Co. Ltd, and Zimmer Biomet

*Definition: Hydroxyapatite is a natural mineral that occurs in the body and has similar chemical characteristics to bone. It is therefore an effective bone substitute that can be used to replace or reshape bone lost due to injuries, surgery or osteoporosis