Graft Versus Host Disease MarketSize and Trends

High investment in research and development is expected to favor growth of the graft versus host disease market:

In the recent past, the graft versus host disease market has significantly evolved with the introduction of biological and patented small molecule immunosuppressive therapies and been added to the treatment regime. The current research and development programs in Gvhd are equipped with novel therapies such as Adienne Pharma’s Begedina and mesenchymal stem cell therapies. R&D strategies in Gvhd are characterized by an increasing trend towards maintaining appropriate prophylactic regimens and inhibiting proliferation and activation of T-cell. Such regimens in Gvhd are tailored to conditioning and transplant type and used for hematopoietic stem cell transplantation (HSCT). However, there is significant possibility of risk of opportunistic infection during this process.

However, most of the ventures in research and development process, including academically running clinical studies regarding targeting niche subgroup under Gvhd such as steroid refractory aGVHD and cGVHD, are key R&D strategies in the GVHD pipeline, with around 30 products in the pipeline targeting such populations. Extensive research and development activities are expected to favor growth of the graft versus host disease industry in the near future.

Large unmet needs in the Gvhd management are one of the most important factors fueling growth of the graft versus host disease market. At present there are very few or no guidelines for management of graft versus host disease that can precisely maintain the data for the large population suffering from Gvhd, though certain recommendations for such therapies are in place.

Market players in the GvHD market focusing on inorganic growth strategies to strength product portfolio

The global graft versus host disease market is competitive and fragmented. Major players in the market are developing novel products and spending significantly in research and development, along with major acquisitions and collaborations to achieve competitive edge over their counterparts. For instance, Kalytera Therapeutics, Inc. acquired Talent Biotechs Ltd. – an Israeli-based developer of proprietary cannabidiol therapeutic. This is expected to favor the increase in company’s product portfolio. Some of the key players in the Gvhd market are Sanofi, Novartis AG, Neovii Biotech GmbH, Merck & Co., Astellas Pharma Inc., Soligenix, Inc., and Mesoblast Ltd.