GENE PANEL MARKET ANALYSIS

Gene panel test is a genetic testing tool which sequences the whole genome of the patient suspected to be suffering from diseases caused due to genetic mutations or are genetically inherited such as cancer, cardiovascular diseases, and others. Few applications of gene panel include pharmacogenetics, diagnosis of congenital disorders, and for cancer risk assessment. Gene panel is an important diagnostic tool for early detection and prediction of rare genetic mutations that cause diseases such as Lynch Syndrome (hereditary non-polyposis colorectal cancer) as it puts people at higher risk than other types of cancers such as stomach, ovarian, and colon. Targeted gene panels can be used for analysis of specific gene mutation associated with the disease or associated with the phenotypic characteristic that is under study/research. Recent advances in the field of gene sequencing has led to the development of customized gene panels as required by the user.

Global Gene Panel Market - Impact of the Coronavirus (COVID-19) Pandemic

Coronavirus (COVID-19) outbreak was first reported on December 31, 2019, in Wuhan, China. The World Health Organization declared COVID-19, as pandemic on March 11, 2020.

According to the Coronavirus (COVID-19) Weekly Epidemiological Update by the World Health Organization, over 186,240,393 cases and 4,027,861 deaths due to coronavirus disease (COVID-19) were reported till July 11, 2021, across the globe.

Impact of COVID-19 on Demand and Supply of Gene Panel

The COVID-19 pandemic and lockdown in various countries across the globe have impacted the financial status of businesses across all sectors. The COVID-19 pandemic has impacted the entire supply chain of the biotechnology industry mainly due to strict lockdown in several regions. The coronavirus pandemic has impacted development, production, and supply of healthcare products and affected businesses of various companies operating in the healthcare sector across the globe. The pandemic has led to the closure of industrial establishments, except manufacturing of essential commodities, and disruption in supply chain of healthcare products.

However, the rising incidences of cardiovascular diseases, arthritis, and neurological diseases associated with COVID-19 infection are expected to have a positive impact on the market growth of gene panel, as gene panels can be used for the detection of such diseases. For instance, according to an article published by the JAMA Cardiology Journal in July 2020, a gene panel consisting of six pro-inflammatory genes was used to show that the activity of these genes was higher in heart of COVID-19 patients as compared to the COVID-19 negative population. According to an article published by the National Centers for Biotechnology Information in January 2021, a study conducted in Wuhan, China, revealed that out of 221 COVID-19 positive patients, approximately 5% had ischemic stroke and 0.5% had hemorrhagic stroke. In another study from the same region, out of 214 COVID-19 positive patients, about 5.7% people with severe COVID infection were reported with acute cerebrovascular disease.

Thus, impact of the coronavirus (COVID-19) pandemic is expected to aid the growth of the global gene panel market during the forecast period, owing to the need for reliable gene panels as a diagnostic tool for detection of comorbid diseases associated with COVID-19 infection.

The global gene panel market is estimated to be valued at US$ 22,044.7 Mn in 2021, and is expected to exhibit a CAGR of 20.2% over the forecast period (2021-2028).

Figure 1: Global Gene Panel Market Share (%) Analysis, By Technique, 2021

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The increasing burden of chronic diseases is the major factor that is expected to drive the market growth of gene panel over the forecast period.

The rising burden of chronic diseases which are associated with genes such as stroke, heart attack, cancer, arthritis, and others are expected to drive growth of gene panel market over the forecast period. According to the data provided by the International Agency for Research on Cancer (IRAC) in 2018, it is estimated that there will be more than 27.5 million new cancer cases by 2040, which would be majorly due to factors such as unhealthy lifestyle, smoking, and reduced physical activities. Also, according to the statistics provided by the World Health Organization in 2018, over 795,000 people have stroke each year in the U.S. This is expected to create opportunities for gene panel market as a clinical diagnostic tool.

The rising number of product launch and approval is expected to drive the growth of the global gene panel market over the forecast period. For instance, in September 2020, Bionano Genomics, an American genomic diagnostics manufacturer, announced the launch of EpiPanelDx PLUS, which is a gene panel test for diagnosis of epilepsy.

Global Gene Panel Market – Restraints

However, growth of the gene panel market may be hampered, owing to inability of next generation sequencing (NGS) gene panels in detecting some allelic mutations. According to an article published by the Scientific Electronic Library Online in 2019, NGS based gene panels were found to be inefficient in detecting some allelic mutations associated with lysosomal storage disorders (LSD).

Global Gene Panel Market – Regional Analysis

On the basis of region, the global gene panel market is segmented into North America, Latin America, Europe, Asia Pacific, Middle East, and Africa.

North America is expected to hold dominant position in the global gene panel market over the forecast period, owing to rising collaborations and partnerships between market players. For instance, in October 2019, Illumina, Inc., an American biotechnology company, and QIAGEN, a German molecular diagnostic company, announced a 15-year partnership to boost the distribution of next generation sequencing-based diagnostic kits to be used in conducting gene panels.

Figure 2: Global Gene Panel Market Value (US$ 8,773.8 Mn), by Region, 2021

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Global Gene Panel Market – Competitive Landscape

Major players operating in the global gene panel market include Thermo Fisher Scientific Inc., BGI, GENEWIZ, Inc., GATC Biotech, Novogene Co., Ltd., QIAGEN, Integrated DNA Technologies, Inc., Illumina Inc., Agilent Technologies, Inc., Eurofins Scientific, F. Hoffmann-La Roche Ltd, Personalis Inc., GeneDx Inc., and Invitae Corporation