GEL PERMEATION CHROMATOGRAPHY MARKET ANALYSIS

Market Challenges And Opportunities

• High cost associated with gel permeation chromatography system 

Global Gel Permeation Chromatography (GPC) Market: Restraint

The major factors that hinder growth of the global gel permeation chromatography market include high cost associated with gel permeation chromatography system and its components, which limits use of the instrument in academic institutes except pharmaceutical companies. Other analytical instruments such as Liquid chromatography-Mass Spectrometry (LC-MS) are more widely used, due to large number applications such as characterization, detection, analysis, quantification, which is expected to restrict growth of the gel permeation chromatography market.

• Rise in research and development by pharmaceutical and biotech companies in chronic disease  
• Regulatory approvals for use of novel excipients (Polymers) is expected to drive growth of the gel permeation chromatography market over the forecast period

Global Gel Permeation Chromatography (GPC) Market: Key Developments

In September 2020, according to an article published by Royal Society of Chemistry, it was revealed that Water Advanced Polymer Chromatography (APC) technology  is supported well by gel permeation chromatography (GPC), gel permeation elution chromatography (GPEC), and hydrophilic interaction liquid chromatography (HILIC) for increasing the sophistication of research and boosting flexibility for the analysis of complex polymer blends.

Regulatory approvals for use of novel excipients (Polymers) in drug development is expected to drive growth of the gel permeation chromatography market over the forecast period.

Pharmaceutical and biotech companies widely use polymers as excipient (Binder, Diluent, coating agents, suspending agent, viscosity agent, and Disintegrant) to produce a variety of dosage forms for the medicines. There is increasing use of natural polymers instead of synthetic ones due to their inertness, low cost, and higher acceptability of consumers towards natural polymers. Recently launched natural polymers from different manufacturers are Solutol HS 15, Soluplus, Kollicoat Smartseal 30 D, Polyplasdone Ultra, and Prosolv ODT. However, before using polymers in formulation, end users (pharmaceutical and biotech companies) have to be confident about quality of polymers used as excipients. U.S. Food and Drug Administration (US FDA) demands Quality by Design in manufacturing the formulations (non-adherence otherwise leads to product recalls). Therefore companies have to characterize these polymers for quality parameters. This needs efficient GPC systems. Moreover, companies have to adhere to International Council for Harmonisation (ICH) guideline (M4Q), which requires novel excipients to characterize their functionality and physicochemistry. For instance, in October 2019, National Center for Biotechnology Information claimed that ethylcellulose is a pharmaceutical excipient with multidirectional application in drug dosage forms development using gel permeation chromatography system as analytical technique.