COLLAGEN FILLER MARKET ANALYSIS

Global collagen filler market is estimated to be valued at US$ 486 million in 2023, and is expected to exhibit a CAGR of 7.4% during the forecast period (2023-2030).

Analysts’ Views on Global Collagen Filler Market:

Increasing numbers of cosmetic related surgeries, new product launches, and strategies like mergers, acquisitions, and collaboration are expected to drive the global collagen filler market growth over the forecast period. For instance, according to The Aesthetic Surgery Society, 2022, surgical procedures had increased by 54% in the U.S. in 2021. According to the report published by The Aesthetic Society, in April 2022, total 1,857,339 dermal filler surgeries were performed in 2021 indicating42% increase from surgeries in 2020.

Figure 1. Global Collagen Filler Market Share (%), By Product Type, 2023

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Global Collagen Filler Market – Drivers

Increasing launch of new products in collagen fillers

Increasing launch of new products in collagen fillers is expected to drive the global collagen filler market growth over the forecast period. For instance, in September 2022, the U.S. Food and Drug Administration approved Daxxify, manufactured by Revance Aesthetics, a U.S.- based aesthetics company. It is a new drug that may reduce the appearance of facial wrinkles for about six months, and can be an alternative to Botox.

Increasing launches of new technologies

Increasing launches of new technologies is expected to drive the global collagen filler market growth. For instance,  according to the article published by Journal Gels, on May 23, 2022, an innovative technology for manufacturing collagen based dermal fillers was developed. This HACL-CTL (cross-linked hyaluronic acid and lactose modified chitosan) technology uses minimum amount of crosslinking agents, as these are toxic, and associated with several adverse reactions. New fillers based on collagen, functionalized with 1,4-butanediol diglycidyl ether and lactose modified chitosan were used.

Figure 2. Global Collagen Filler Market Share (%), By Region, 2023

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Global Collagen Filler Market - Regional Analysis

Among region, since collagen filler injections are a sort of aesthetic non-invasive surgery, North America is anticipated to have a prominent position in the global collagen filler market throughout the forecast period. For instance, according to American Society of Plastic Surgeon Report 2020, approximately 13.2 million cosmetic procedures were carried out in U.S. in 2020, out of which, 3.4 million were soft tissue fillers. Thus, rising cosmetic surgeries is anticipated to drive the market growth over the forecast period.

Global Collagen Filler Market – Impact of Coronavirus (COVID-19) Pandemic

Since the COVID-19 virus outbreak in December 2019, the disease has spread to over 100 countries across the globe, and the World Health Organization declared it a public health emergency on January 30, 2020.

COVID-19 affected the economy in three main ways: by directly affecting the production and demand of drugs, by creating disruptions in distribution channels, and through its financial impact on firms and financial markets. Due to nationwide lockdowns, several countries, such as China, India, Saudi Arabia, the U.A.E., Egypt, and others faced problems regarding transportation of drugs from one place to another.

However, the COVID-19 pandemic had negative impact on the global collagen filler market, due to strict regulation that resulted in closing of industries. This caused less manufacturing and demand for collagen based filler products during pandemic situation. For instance, according to Allergen Aesthetics, a U.S.-based pharmaceutical company global revenue of Juvederm, a product developed by Allergen Aesthetics  was reduced by 40.2 % in 2020 compared to 2019. Revenue in 2020 was US$ 718 Million while it was nearly US$ 1,243.7 Million before pandemic in 2019.

Global Collagen Filler Market- Segmentation

Global collagen filler market report is segmented into product type, source, application, end user, and region.

Based on product Type, the global collagen filler market is segmented into collagen with PMMA and collagen without PMMA. Out of which, the collagen with PMMA segment is expected to dominate the market due to increasing launch of products.

Based on source, the global collagen filler market is segmented into bovine, porcine, and others. Out of which, the bovine segment is expected to dominate the market due to increasing research and development of bovine based products.

Based on application, the global collagen filler market is segmented into face rejuvenation, wrinkles, scar treatment, lip treatment, cellulite reduction, and others. Among these, face rejuvenation segment is expected to dominate the market over the forecast period due to increasing demand for face rejuvenation in market.

Based on end user, the global collagen filler market is segmented into hospitals, dermatology clinics and others. Out of which, the hospital segment is expected to dominate the market due to increasing cosmetic procedures performed in hospitals.

Based on Region, the global collagen filler market is segmented into North America, Europe, Asia Pacific, Latin America, Middle East, and  Africa. Among these, North America is expected to dominate the market over the forecast period due to increasing launch of newer products in this region.

Among all segmentation, the product type segment has the highest potential due to increasing launch by the key market players. For instance, on April 20, 2021, Lonza, a Switzerland-based multinational manufacturing company for the pharmaceutical, biotechnology, and nutrition sectors, announced the expansion of UC-II undenatured collagen ingredient line. It is made with organic collagen and non-GMO project verified. Non-GMO means a product was produced without genetic engineering.

Global Collagen Filler Market- Cross Sectional Analysis

Among application, the face rejuvenation segment is dominant during the forecast period in Europe region, due to increasing cosmetic surgeries. For instance, according to the British Association of Aesthetic Plastic Surgeons, 2022, 31,057 cosmetic procedures were performed in 2022, indicating 102% increase from 2021.

Global Collagen Filler Market: Key Developments

In November 2022, LifeSprout, a U.S.-based regenerative medicine company, announced positive six-month interim results from its pivotal clinical trial of Lumina, a collagen filler. Lumina achieved its primary endpoint of correction of moderate-to-severe nasolabial folds (NLF) with good safety.

According to data published by Good clinical practice network, a multidisciplinary and multilingual platform by the World Health Organization on March 10, 2023, clinical trials are being conducted by SciVision Biotech Inc., company engaged in the manufacturing and distribution of hyaluronic acid medical supplies for evaluation of the safety and effectiveness of a novel gel-type sodium hyaluronate for the orrection of aging mid-face.

On March 4, 2021, Galderma, a Switzerland-based dermatology company, announced a European re-launch of Sculptra (injectable poly-L-lactic acid), a collagen stimulator,  with an updated administration protocol. The product is ready for use more quickly following reconstitution, with increased levels of comfort for patients.

On September 23, 2021 Galderma, a Switzerland-based dermatology company, and Sofregen Medical, Inc., a U.S.-based medical device company, announced that both companies had signed a co-development and option-to-acquire agreement. This agreement will broaden Galderma's capabilities, which are founded on decades of science-based aesthetics innovation in biostimulator and hyaluronic acid (HA) fillers.             

Global Collagen Filler Market: Key Trends

Collaborations between key market players

Different medical aesthetic companies are adopting strategies such as collaborations, and agreements, and this is expected to drive the market growth within forecast period. For instance, on May 9, 2023, Evolus, a U.S.-based medical aesthetic company, collaborated with Symatese, a France- based surgical products company, and announced its expansion into U.S. Dermal Filler Market with Evolysse, a First-Generation Cold Technology hyaluronic acid.

Research and development by key market players

Increasing research and development activities by market players is expected to drive the global collagen filler market growth over forecast period.According to the data published on December 3, 2021, by clinical trial site of U.S. National Library of Medicine, clinical trials were carried out by Dr. Korman Laboratories Ltd., an Israel- based aesthetic medicine company, for assessing Safety and Performance of Depolymerized kraft lignin Crosslinked Sodium Hyaluronate 23 Dermal Filler for improvement of nasolabial fold Appearance, started in 2021.

Global Collagen Filler Market: Restraints

Side effects of collagen fillers

Collagen fillers are associated with several side effects. These side effects may impact on the market growth. For instance, according to the article published by U.S. Food and Drug Administration on April 2, 2022, the collagen fillers are associated with side effects such as bruising, redness, swelling, pain, tenderness, itching, rash, and difficulty in performing activities. The most serious risk associated with these filler is accidental injection into blood vessels. Fillers that enter a blood vessel can cause skin necrosis, stroke, or even blindness.

To counterbalance this restraint, a safe procedures with minimum side effects must be developed.

Availability of alternative methods

Majority of the collagen fillers currently available are absorbable / bio degradable. Biodegradable fillers last for 3 to 24 months, whereas, PMMA fillers last for 4-5 years. This makes the procedure repetitive after the certain time that can lead to a shift towards surgical facial rejuvenation instead of dermal fillers, and limits the market growth. According to a blog published by Aedit, an online Aesthetic resource, on May 8, 2020, facial fat transfer can also be an alternative to collagen fillers.

To counterbalance this restrain, more awareness on collagen fillers should be spread.

Global Collagen Filler Market - Key Players

Major players operating in the global collagen filler market include Allergan, Inc., Johnson & Johnson Private Limited, Collplant Holdings Ltd, Ortho Dermatologics, Inc., Suneva Medical, Inc., Merz Pharma GmbH & Co. KGaA, Surgical Specialties Corporation, Sinclair Pharma, Inamed GmbH, and Endo International plc.

*Definition: Collagen dermal fillers are used for treating minor imperfections of facial skin such as wrinkles, creases, face lines, crow’s feet and acne stars. Collagen fillers are also used for creating full lips and cheeks, and can also be used to treat areas of the back, neck and chest. In some cases, facial collagen injection are combined with procedures such as face lift procedures or face rejuvenating. Dermal fillers such as collagen fillers have temporary cosmetic effect as these contain materials such as collagen that is absorbed by the body in a particular interval of time.