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Rising adoption of combination therapiesThere is a growing recognition in the oncology space that monotherapies may have limited efficacy against many solid tumor cancers. Combination therapies that amalgamate the mechanisms of two or more treatment types are demonstrating improved clinical outcomes as compared to single drug therapies. The paradigm is steadily shifting from sequential single agent treatments to rational combination regimens. Immunotherapy combinations that incorporate other modalities like targeted therapies, chemotherapy, and radiotherapy are showing especially promising results by overcoming the immune escape mechanisms. For example, combining immune checkpoint inhibitors like anti-PD-1/PD-L1 drugs with angiogenesis inhibitors is enhancing anti-tumor responses. The success of 'chemio-immunotherapy', which involves immune therapies along with chemotherapy, has encouraged many such combination trials.
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