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Improving Outcomes and Lowering Transplant Risks
There have been major technological and procedural advancements that have helped lower transplantation risks and improved clinical outcomes for bone marrow transplant patients. Developments such as reduced-intensity conditioning regimens, better donor matching algorithms, advances in graft engineering, more effective graft-versus-tumor effects and improved options for preventing and treating complications have collectively boosted success rates of these transplant. For example, use of reduced-toxicity non-myeloablative transplant protocols have made the procedure accessible for older and less fit patients who were earlier not considered eligible. The use of haploidentical donor grafts from family members instead of perfectly matched unrelated donors has broadened the donor pool. Advancements in post-transplant care involving targeted infection prophylaxis, supportive care therapies and immune modulation have also enhanced survival. These evolving best practices and newer technologies are enabling clinicians to adopt more liberal transplant indications. As a result, eligible patient populations are expanding beyond traditional limits. Growing confidence in the procedure has led to increased acceptance amongst patients as a curative approach, thus, boosting demand.
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