Limitations of aptamers can hamper the global aptamers market growth. For instance, in August 2020, according to the data published in Journal of Nanobiotechnology, titled “Role of Novel Drug Delivery Vehicles in Nano biomedicine,” aptamers are well-established therapeutic molecules with high specificity and affinity to their target as comparable to monoclonal antibodies. As aptamers have advantages over antibodies, it also have some limitations that hindered their widespread clinical use as a therapeutic agent. Some of the limitations include renal filtration, serum stability, endocytic escape, and lack of diversity in the aptamer library, nuclease susceptibility and claims of aptamer specificity as well. Many aptamers are prone to quick degradation in biological media due to interactions with biomolecules.
Market Opportunities – Wide Applications of Aptamers
The wide range of applications of aptamers across diagnostics, therapeutics, and other industries is expected to boost its demand. Furthermore, the advantages of aptamers over antibodies such as ease of production and chemical modification is expected to increase its adoption.
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