ANHYDROUS DIBASIC CALCIUM PHOSPHATE MARKET ANALYSIS

Global anhydrous dibasic calcium phosphate market is estimated to be valued at US$ 213.5 million in 2023 and is expected to exhibit a CAGR of 5.7 % during the forecast period (2023-2030).

Analysts’ views on global anhydrous dibasic calcium phosphate market:

Increasing number of geriatric population result in increasing demand for food supplements. This is expected drive the global anhydrous dibasic calcium phosphate market growth over the forecast period. For instance, according to the data published by the World Health Organization on October 1, 2022, by 2030, 1 in 6 people in the world will be aged 60 years or over. At this time the share of the population aged 60 years and over will increase from 1 billion in 2020 to 1.4 billion. By 2050, the world’s population of people aged 60 years and older will double (2.1 billion). The number of persons aged 80 years or older is expected to triple between 2020 and 2050 to reach 426 million.

Figure 1. Global Anhydrous Dibasic Calcium Phosphate Market Share (%), By Source, 2023

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Global Anhydrous Dibasic Calcium Phosphate Market– Drivers

Increasing launches of new supplements

Increasing launches of new supplements is expected to drive the global anhydrous dibasic calcium phosphate market growth over the forecast period. For instance, on January 06, 2022, Nutrazee, India based premium vegan supplement brand, announced the launch of Calcium + Vitamin D gummies for kids & adults. Nutrazee’s Calcium + D3 gummies are intended to supplement diet with calcium and vitamin D, which help support the bone health, teeth, and immune health. The gummies are 100% vegan and come in natural orange flavor. These are made of pectin (sourced from fruit), a plant-based alternate to animal-derived gelatin. The calcium is mainly prepared from anhydrous dibasic calcium phosphate which is expected to drive growth of global anhydrous dibasic calcium phosphate market.

Increasing research & development activities in anhydrous dibasic calcium phosphate

Increasing research & development activities in anhydrous dibasic calcium phosphate is expected to drive the global anhydrous dibasic calcium phosphate market growth. For instance, according to an article published by the Journal of Orthopedic Translation on February 03, 2022, a porous scaffold composed of pure magnesium particles and coated with dibasic calcium phosphate dehydrate (DCPD) coating were prepared using 3D gel printing technology. It was found that due to coating with DCPD, porosity and pore size can be controlled independently and accurately. The DCPD coated pure granular scaffold has suitable initial mechanical properties, good biocompatibility, and suitable degradation rate, which stimulates bone regeneration and mediates new bone formation and remodeling.

Figure 2. Global Anhydrous Dibasic Calcium Phosphate Market Share (%), By Region, 2023

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Global Anhydrous Dibasic Calcium Phosphate Market - Regional Analysis

Among region, Asia Pacific is estimated to hold a dominant position in the global anhydrous dibasic calcium phosphate market over the forecast period, owing to increasing research & development in this region. For instance, according to an article published by Materials Letters on April 22, 2020, Incorporation of alginate-hyaluronic acid micro beads in injectable calcium phosphate cement can be used to improve bone regeneration. The embedment of alginate (ALG)-hyaluronic acid (HA) micro beads into calcium phosphate cement (CPC) hardly altered the setting time and compressive strength. Inject ability and washout resistance were found to be higher in CPC/ALG-HA than only CPC. In-vivo studies in rabbit showed a noteworthy increase in bone formation with CPC/ALG-HA compared to CPC after 8 weeks of implantation. Thus, the developed CPC/ALG-HA could be used as a potential injectable bone substitute for improved bone regeneration.

Global Anhydrous Dibasic Calcium Phosphate Market– Impact of Coronavirus (COVID-19) Pandemic

Since the COVID-19 virus outbreak in December 2019, the disease has spread to over 100 countries across the globe, and the World Health Organization declared it a public health emergency on January 30, 2020.

COVID-19 affected the economy in three main ways: by directly affecting the production and demand of drugs, by creating disruptions in distribution channels, and through its financial impact on firms and financial markets. Due to nationwide lockdowns, several countries, such as China, India, Saudi Arabia, the U.A.E., Egypt, and others faced problems regarding transportation of drugs from one place to another.

COVID-19 had negative impact on the global anhydrous dibasic calcium phosphate market due to reduced manufacturing and supply of drug and excipients in COVID-19 duration. For instance, according to an article published by the International Journal of Business and Management on June 8, 2021, approximately 60% of the world’s active pharmaceutical ingredients (API) were made in China. The shutdown of the majority of the drugs manufacturing facilities caused a shortage in the raw materials and subsequently a drug shortage on the market. The supply chain disruption has many dimensions; lockdown on many countries and restrictions on travel and cargo, shortage in supply due to unavailability of workers or primary materials suppliers and increased demand that exceeded capacity of suppliers.

Global Anhydrous Dibasic Calcium Phosphate Market Segmentation:

Global anhydrous dibasic calcium phosphate market report is segmented into source, end use, and region.

Based on source, the global anhydrous dibasic calcium phosphate market is segmented into hydrochloric acid and phosphoric acid. Out of which, the hydrochloric acid segment is expected to dominate the market due to increasing availability of anhydrous dibasic calcium phosphate obtained from hydrochloric acid.

Based on end use, the global anhydrous dibasic calcium phosphate market is segmented into animal feed, food & beverage, agriculture, pharmaceutical, and others. Among these, pharmaceutical segment is expected to dominate the market over the forecast period due to increasing demand of pharmaceutical products.

Based on region, the global anhydrous dibasic calcium phosphate market is segmented into North America, Latin America, Europe, Asia Pacific, Middle East, and Africa. Among these, Asia Pacific is expected to be dominant over the forecast period due to increasing manufacturing in this region.

Among all segmentation, the source segment has the highest potential due increasing availability of anhydrous dibasic calcium phosphate obtained from hydrochloric acid. For instance, according to an article published by the Journal Pharmaceutics on May 28, 2021, novel calcium phosphate-based starter pellets were used in development of a biphasic-release multiple-unit pellet system (MUPS) by using diclofenac sodium. The calcium phosphate was obtained from hydrochloric acid. A series of performance tests demonstrated that control of the dissolution of the drug substance from the developed formulations was related to the water solubility of their inert cores. It was observed that the anhydrous dibasic calcium phosphate-based starter pellets (DCPA) were able to control the rate of release much better than soluble sugar spheres or isomalt pellets. It can be assumed that the use of more efficient polymers or a greater amount of them would result in a decrease in the dissolution rate. In this respect, DCPA starter pellets offer a very attractive opportunity of improving productivity and controlling the dissolution rate of drugs with a smaller quantity of polymers. Calcium phosphate-based pellets appear to be a particularly promising prospect.

Global Anhydrous Dibasic Calcium Phosphate Market Cross Sectional Analysis:

Introduction of research & development activities in newer applications of anhydrous dibasic calcium phosphate by key market players in Europe region is expected to drive growth of source segment in the region. For instance, according to article published by Nanomaterials on June 8, 2023, a study was conducted to determine whether tricalcium phosphate (TCP), a food additive can be classified as nanomaterials in Europe. The physicochemical properties of TCP were characterized. Three different samples (from a chemical company and two manufacturers) were thoroughly characterized according to the recommendations of the European Food Safety Authority (EFSA). A commercial TCP food additive was identified as actually being hydroxyapatite (HA). It presents itself in the form of particles of different shapes (either needle-like, rod, or pseudo-spherical), which were demonstrated in this paper to be of a nanometric dimension: E341(iii) is thus a nanomaterial. In water, HA particles sediment rapidly as agglomerates or aggregates over a pH of 6 and are progressively dissolved in acidic media until the complete dissolution at a pH of 2. Consequently, since TCP may be considered as a nanomaterial on the European market, it raises the question of its potential persistency in the gastrointestinal tract. This resulted in the conclusion that the E341(iii) food additive, represented by three independent samples, satisfies the definition of a nanomaterial according to the EFSA.

Global Anhydrous Dibasic Calcium Phosphate Market: Key Developments

On May 3, 2023, OceanTech Acquisitions, a U.S.-based a special purpose acquisition company, announced that it has entered into definitive agreement to combine Regentis Biomaterials Ltd., an Israel-based regenerative medicine company at US$ 95 million valuation. Or-Akiva, Israel-based Regentis has been working to commercialize its GelrinC orthopedic therapy to repair cartilage damage in knees and has already received a CE mark in Europe as a medical device. This orthopedic therapy requires anhydrous dibasic calcium phosphate as calcium supplement.  The combined company is expected to trade on the Nasdaq once the deal is completed in the fourth quarter of 2023. Regentis shareholders are to receive US$ 95 million in OceanTech I shares at US$ 10 per share.

On April 11, 2022, Abbott, a U.S.-based global healthcare leader announced launch of Arachitol Gummies in India, a new fruit flavored product for kids and adults. Arachitol Gummies is a dietary supplement that helps maintain required levels of calcium and Vitamin D sustainably. As the body needs vitamin D to absorb calcium for better bone health, keeping recommended levels of vitamin D is essential for overall well-being. Formulated with additional essential micronutrients such as calcium and curcumin, they help support bone health and immunity. Anhydrous dibasic calcium phosphate is most common source of calcium. Launched in orange fruit flavor, these easy-to-consume gummies are approved as health supplements by the Food Safety and Standards Authority in India.

On January 18, 2022, Gadot Biochemical Industries Ltd., an Israel based food, beverage, pharmaceutical, nutritional supplement, and detergent industries announced launch of a new bone support ingredient called Cal2Mag, a combination sources of calcium and magnesium. The mineral blend is substantiated by clinical studies to offset risks of arterial calcification which are associated with supplementing with calcium as a standalone mineral. As anhydrous dibasic calcium phosphate is most common source of calcium, its use in this product can drive growth of market over forecast period.

On February 20, 2023, Apollo and Luna Co., a U.S. based brand offering health supplements of dogs launched its first product, a dog food topper supplement. The topper seeks to add flavor and essential nutrients to standard dog kibble. Formulated with natural ingredients and made in the U.S., the all-natural topper serves as a calcium supplement and flavor enhancer. The supplement is available in a peanut butter flavor and does not contain any artificial colors and flavors or grains.

Global Anhydrous Dibasic Calcium Phosphate Market: Key Trends

Awareness programs arranged for dietary supplements

Awareness programs arranged for dietary supplements can drive growth of market. For instance, on February 16, 2023, Torrent Pharmaceuticals Ltd., an India based multinational pharmaceutical company announced its first-ever 12-week-long campaign across TV and digital. The campaign is named as BeShelcalStrong, to announce entry of its brand Shelcal 500 an over-the-counter (OTC) calcium supplement brand. The TVC created under the campaign aims to address the aforementioned lack of dietary calcium amongst people by educating them to pay heed to their exhaustion and listen to their aching bones, especially after they turn 40. By depicting everyday instances, the film further highlights the need to supplement one’s diet with Shelcal 500 daily.

Launch of newer products containing anhydrous dibasic calcium phosphate

Launch of newer products containing anhydrous dibasic calcium phosphate can drive global anhydrous dibasic calcium phosphate market growth. For instance, on December 5, 2022, Shijiazhuang Junlebao Dairy Co., Ltd., a China based food production company announced launch of Le Gai, a new milk powder targeted at supporting calcium absorption in middle and old aged consumers and hopes to rejuvenate the well-established category by improving bioaccessibility and bioavailability.

Global Anhydrous Dibasic Calcium Phosphate Market: Restraints

High cost of anhydrous dibasic calcium phosphate

The high cost of anhydrous dibasic calcium phosphate is expected to hamper the global anhydrous dibasic calcium phosphate market growth. For instance, according to an article published by the World Bank on May 11, 2022, fertilizer prices have risen nearly 30% since the start of 2022, following last year’s 80% surge. Soaring prices are driven by a confluence of factors, including surging input costs, supply disruptions, and export restrictions. The cost of phosphoric acid and calcium oxide, the starting ingredient in formation of anhydrous dibasic calcium phosphate has increased which increases concerns around fertilizer affordability and availability.

To counterbalance this restraint, more efficient sources and its supply methods should be identified.

Recalls of calcium supplements

Recalls of calcium supplements is expected to hamper the global anhydrous dibasic calcium phosphate market growth. For instance, on March 3, 2020, Purina Animal Nutrition LLC, a U.S. based animal nutrition company, announced voluntary recall of multiple lots of Purina Rabbit Feed, Purina Turkey Feed, Country Acres Rabbit Feed and DuMOR Chick Starter/Grower Feed due to elevated calcium levels in the product. Purina Animal Nutrition received reports from customers claiming the rabbit products may have resulted in poor health and/or mortality. Elevated calcium carbonate levels can cause health issues and potential mortality in rabbits. Continued feeding of these products may result in death as a result of feed refusal. Elevated calcium carbonate levels in young chickens and turkeys can lead to leg abnormalities and kidney calcification.

To counterbalance this restrain, more testing of products should be done to avoid such recalls.

Global Anhydrous Dibasic Calcium Phosphate Market - Key Players

Major players operating in the global anhydrous dibasic calcium phosphate market include CAP Biomaterials, LLC, Kemapco Arab Fertilizers & Chemicals Industries LTD, Merck KGaA, AARTI INDUSTRIES LIMITED, Hindustan Phosphates Pvt. Ltd., Guizhou Zerophos Chemical Co., Ltd. Gujarat Narmada Valley Fertilizers & Chemicals Ltd, Bamni Proteins Limited, Innophos, Mitushi Biopharma, Phosphea, Ecophos Group, and Sudeep Pharma Pvt. Ltd.

*Definition: Anhydrous dibasic calcium phosphate is a type of dicalcium phosphate with the chemical formula CaHPO4. This dibasic calcium phosphate is converted into anhydrous form by using thermal processes. Anhydrous dibasic calcium phosphate is formed by a reactive combination of phosphoric acid, calcium oxide, and heat. It is usually found in noodles, dog food, chicken feed, enriched flour, and cereals. Anhydrous dibasic calcium phosphate is widely used in various end-use industries, such as agriculture, pharmaceuticals, and others.