Market Challenges And Opportunities

Androgen Deprivation Therapy (ADT) Market Drivers

Key players in the market are focusing on research to develop new drugs and broaden the indication label of current drugs for treatment of androgen deprivation therapy (ADT), which is expected to boost the global androgen deprivation therapy (ADT) market growth over the forecast period.

For instance, in February 2018, Janssen Pharmaceutica, a subsidiary of Johnson & Johnson received approval for its drug ERLEADA (apalutamide) in treatment of non-metastatic castration-resistant prostate cancer (CRPC). ERLEADA is a next-generation androgen receptor inhibitor, which belongs to the class of drugs anti-androgens and blocks the effect of testosterone to slow down the process of tumor growth and metastasis. It is the first U.S. Food and Drug Administration (FDA) approved drug for the treatment of patients with non-metastatic CRPC.

Similarly, in July 2018, Pfizer Inc. and Astellas Pharma Inc. received approval from the U.S. FDA for XTANDI (enzalutamide) that is indicated for the treatment of non-metastatic CRPC along with its existing indication for CRPC. XTANDI is an androgen receptor inhibitor and works by inhibiting the effects of testosterone, thereby slowing tumor growth and metastasis. These factors are expected to have a positive impact on the global androgen deprivation therapy (ADT) market growth over the forecast period.

Androgen Deprivation Therapy (ADT) Market Restraints

According to American Cancer Society (ASC), several prostate cancers, which are treated with ADT develop resistance to the treatment over a period of time (few months or years). Hormone therapy is not useful in treating hormone refractory prostate cancer i.e. cancer, which is no longer responding to hormone therapy. According to National Cancer Institute (NCI), National Institutes of Health (NIH), along with prostate, androgens also contribute to functions of other organs. Therefore, hormone deprivation therapy is associated with side effects such as hot flashes, loss of bone density, erectile dysfunction, lowered libido, loss of muscular strength mass, insulin resistance, and change in blood lipids, fatigue, mood swings, weight gain and gynecomastia. These factors are expected to restrain the global androgen deprivation therapy (ADT) market growth over the forecast period.