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Advancing Understanding of Immunotherapy's Mechanisms and BenefitsBasic and clinical research over the past decade has significantly expanded knowledge of how allergen immunotherapy works at the molecular level to provide long-lasting relief. Its complex effects on immune cells, cytokines and antibodies responsible for modifying the body's response to allergens are now increasingly well characterized. This growing scientific evidence base is enabling refinement and targeting of immunotherapy protocols. It is also translating to demonstrable real-world advantages over existing symptomatic therapies which treat only a fraction of patients successfully. Studies following thousands of patients for many years now prove immunotherapy can prevent new sensitizations from developing in addition to treating existing ones. Multiple long-term outcome studies also confirm that its benefits endure for 3-5 years after discontinuation of treatment. This disease-modifying impact sets it apart and raises expectations of altering the natural history of allergy in susceptible individuals
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