ADVANCED GLYCATION END PRODUCTS MARKET ANALYSIS

Advanced Glycation End Products Market Size and Trends

Global advanced glycation end products market is estimated to be valued at US$ 1.75 Bn in 2024 and is expected to reach US$ 2.78 Bn by 2031, exhibiting a compound annual growth rate (CAGR) of 6.8% from 2024 to 2031.

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Rising burden of diabetes and increasing adoption of unhealthy lifestyle habits can drive the market growth. Increasing investment by major market players for the development of novel drugs for the treatment of diabetes-related can also drive the market growth. Furthermore, growing obesity rates worldwide along with increasing geriatric population prone to diabetes and associated co-morbidities can drive the market growth over the forecast period.

Increasing prevalence of diabetes and obesity

Rising prevalence of diabetes and obesity can drive the market growth. Diabetes, in particular type 2 diabetes, is a major risk factor for the development of advanced glycation end products in the body. When blood sugar levels remain elevated for prolonged periods in diabetes, it leads to non-enzymatic glycation of proteins and lipids through a chain of complex chemical reactions. This process of glycation and the subsequent rearrangement of amino acids forms AGEs. Similarly, obesity is a chronic metabolic condition characterized by increased adiposity and insulin resistance, often preceding the onset of type 2 diabetes. The accumulation of excess body fat promotes oxidative stress and inflammation in tissues, two pathogenic processes strongly linked to AGE formation. As per estimates by health organizations, the total number of adults with diabetes had nearly quadrupled worldwide between 1980 to 2014. Rising prevalence of diabetes and obesity contributes to a greater disease burden from AGEs. This boosts demand for anti-AGE therapeutics. For instance, on June 23, 2024, according to the studies presented at the ADA's 84th Scientific Sessions in Orlando, advancements in GLP-1 receptor agonists can treat obesity. These developments come amid increasing concerns as obesity affects 125 million Americans, including 41.9% of adults and 19.7% of children. With 90% of diabetes patients grappling with overweight or obesity, the research aims to provide new solutions globally, according to Dr. Robert Gabbay,chief scientific and medical officer.

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Increasing lifespan and aging population

With significant improvements in public health and modern medicine there has been increase in life expectancy. People are now living longer than before. However, aging is an important risk factor for several chronic and degenerative diseases. As human body grows older, the natural process of AGE accumulation also accelerates due to slower tissue turnover and repair mechanisms. Aged tissues and organs exhibit markedly elevated AGE levels as compared to the young people. Aging is often accompanied by gradual decline in kidney function, which impairs the elimination of AGEs from the circulation. All these age-related changes increase burden of AGE. With growing geriatric population, age-related conditions requiring long-term management also increases. Thus, rising population of elderly individuals can boost use of anti-AGE therapies for the prevention and treatment of accelerated aging and age-related pathologies. New research exploring the pathological effects of AGEs have also drawn scientific and clinical interest in AGE-targeted drug development for different aging populations.