ACUTE BACTERIAL SKIN AND SKIN STRUCTURE INFECTIONS MARKET ANALYSIS

Acute Bacterial Skin And Skin Structure Infections Market Size and Trends

Global acute bacterial skin and skin structure infections market is estimated to be valued at USD 3,842.5 Mn in 2024 and is expected to reach USD 5,701.7 Mn by 2031, exhibiting a compound annual growth rate (CAGR) of 5.8% from 2024 to 2031.

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There has been increase in prevalence of acute bacterial skin and skin structure infections worldwide due to changing lifestyles and environmental conditions.  The market growth is driven by increasing number of surgical procedures that require post-operative infection management. Rising geriatric population prone to such infections further drive the market growth.

 Increasing Product Launches by Key Market Players

Market players are involved in launching new drugs, and this is expected to drive growth of the global acute bacterial skin and skin structure infections market over the forecast period. For instance, on July 7, 2021, Melinta Therapeutics, a pharmaceutical company, launched its product- KIMYRSA. KIMYRSA is a lipoglycopeptide antibiotic that provide a complete course of treatment for acute bacterial skin and skin structure infections. KIMYRSA is effective in a single dose of 1200mg injection.

Market Concentration and Competitive Landscape

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One of the key drivers fueling growth of global acute bacterial skin and skin structure infections market is rising prevalence of various types of skin infections across both developed and developing regions. Skin and soft tissue infections include a wide range of conditions that affect the epidermis and soft tissues just below the skin. These infections can range from relatively minor and superficial infections to serious and even life-threatening deep infections. Cellulitis is one of the most common acute bacterial skin infections characterized by diffuse swelling and inflammation of the deep layers of the skin and subcutaneous tissues. According to various studies, the global incidence of cellulitis is estimated to be between 33 to 126 cases per 100,000 population per year. The rate of hospitalization due to cellulitis has also increased significantly over the last decade. Increasing prevalence of cellulitis can primarily be attributed to factors such as aging population, rising incidence of diabetes - a major risk factor, and increased microbial resistance. Similarly, wound and surgical site infections are also becoming more common globally due to growing number of surgeries and invasive procedures performed every year.

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Increasing side effects associated with the available drugs such as tigecycline for the treatment of acute bacterial skin and skin structure infections can hamper growth of the global acute bacterial skin and skin structure infections market over the forecast period. For instance, according to the National Institute of Health, U.S., Tigecycline injection have many side effects such as dizziness, vomiting, diarrhea, nausea, headache, pain, itching of the vagina, and others. These side effects may turn into severe symptoms such as heart attack or some forms of cancer.

Market Opportunity – Rising Awareness about Treatment and Prevention

Rising awareness about treatment and prevention could provide significant opportunities for growth in the global acute bacterial skin and skin structure infections market in the near future. Various awareness campaigns by non-profit public health organizations have highlighted the importance of completing the prescribed course of antibiotics and seeking medical advice for recurring or severe symptoms. Rising awareness directly impacts patients' healthcare seeking behavior and compliance with medications. More individuals are now willing to visit a doctor or clinic at the first signs of infection like redness, swelling or pus, rather than adopting an avoidant approach. As a result, infections are caught at an early stage allowing for quicker recovery through appropriate antibiotic therapy. Early detection and management can prevent infections from spreading deeper into tissues or the bloodstream, thus, reducing the need for interventions like surgical drainage or hospitalization.

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Drug Type segment is sub-segmented into oral & parenteral antibiotics and topical antibiotics. Oral & parenteral antibiotics sub-segment is estimated to hold 53.5% of the market share in 2024, owing to their high efficacy against a wide range of bacterial infections. Oral antibiotics are the most preferred first line of treatment due to their ease of administration through the oral route. Parenteral antibiotics are used when oral administration is not possible due to nausea, vomiting or other reasons. These provide a higher degree of bioavailability as the drug directly enters the bloodstream after intravenous injection or infusion. This ensures greater tissue penetration and achievement of therapeutic drug levels quickly. Parenteral antibiotics play a crucial role in treating severe cases of ABSSSI that have progressed to bacteremia or sepsis. Several new generation injectable antibiotics with activity against drug-resistant strains are expanding the use of parenteral drugs.

Insights, By Infection Type: High occurrence in hospitals drives Hospital Acquired ABSSSI segment

Infection Type segment is sub-segmented into hospital acquired ABSSSI and community acquired ABSSSI. Hospital acquired ABSSSI sub-segment is estimated to hold 57.1% of the market share in 2024, due to its high occurrence in hospital settings. Healthcare associated ABSSSI constitutes a major burden in hospitals due to increasing antimicrobial resistance and complex patient profiles seen in tertiary care centres. Prolonged hospital stay, surgery/trauma, insertion of medical devices like catheters, joint replacements and others compromises the skin integrity, thus, making patients vulnerable to exogenous nosocomial infections.

The hospital environment serves as a reservoir for multi-drug resistant organisms. Pathogens like MRSA, VRE, ESBL-producing bacteria and Pseudomonas aeruginosa that cause virulent ABSSSI are commonly acquired through contact with colonized or infected patients, health workers or contaminated surfaces/equipment in hospitals. Immune-suppressed patients undergoing cancer therapy or organ transplantation are at high risk of severe hospital acquired infections. Without timely treatment, these infections can lead to life threatening sepsis.

Insights, By Distribution Channel: Logistic advantages drive Hospital Pharmacies distribution channel

Distribution Channel segment is sub-segmented into hospital pharmacies, retail pharmacies, online pharmacies. Hospital pharmacies sub-segment is estimated to hold 43.8% of the market share in 2024 owing to logistic advantages over other channels. ABSSSI patients are commonly treated within a hospital setting by specialists like dermatologists or infectious disease physicians. Hospital pharmacies are equipped to provide the extensive formulary that includes both conventional and specialized parenteral anti-infectives needed for managing severe cases. The pharmacovigilance activities like therapeutic drug monitoring are also more feasible when the patient is hospitalized. Retail pharmacies and online channels have limitations in providing these specialized services. Home healthcare gained prominence during the pandemic but hospital admissions are still preferred for resistant/complicated ABSSSI.

Regional Insights

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North America remains the dominant region in the global acute bacterial skin and skin structure infections market and is estimated to hold 36.7% of the market share in 2024 due to  factors such as high per capita healthcare expenditure and presence of many leading industry players in the region. The U.S. accounts for the largest share in the North American market due to wide availability of advanced treatment options and growing awareness about skin infections and their management. Moreover, the reimbursement.

Asia Pacific has emerged as the fastest growing regional market for acute bacterial skin and skin structure infections treatment. Countries like China, India, Japan and South Korea are witnessing increasing prevalence of various skin infections due to growing urbanization, expanding industrial sectors and changing lifestyles. Rising incidence of hospital-acquired and surgical-site skin infections have also boosted demand for effective antibacterial drugs in Asia Pacific nations. Growing medical tourism and rising per capita incomes have made advanced treatment more affordable in the region. Furthermore, the presence of many global pharmaceutical manufacturers in Asia Pacific through their regional production facilities ensures adequate supply and lower prices of drugs.

Market Report Scope

Acute Bacterial Skin And Skin Structure Infections Industry News

• In July 2021, AbbVie, Inc., a biopharmaceutical company, announced that the U.S. Food and Drug Administration had approved DALVANCE (dalbavancin) for the treatment of acute bacterial skin and skin structure infections (ABSSSI) in pediatric patients. DALVANCE is the first single-dose option administered as a 30-minute intravenous (IV) infusion for the treatment of ABSSSI caused by designated susceptible Gram-positive bacteria in pediatric patients, including infections caused by methicillin-resistant Staphylococcus aureus (MRSA).
• In March 2021, Melinta Therapeutics LLC, a pharmaceutical company, announced that the U.S. Food and Drug Administration (FDA) had approved KIMYRSA (oritavancin) for the treatment of adult patients with acute bacterial skin and skin structure infections (ABSSSI) caused by susceptible isolates of designated Gram-positive microorganisms, including methicillin-resistant Staphylococcus aureus (MRSA).

*Definition: Acute bacterial skin and skin structure infection is a bacterial infection of skin and skin related tissues such as Epidermis tissue. Acute bacterial skin and skin structure infections is a cluster of common types of infection including abscesses, cellulitis, and wound infections, which requires an immediate effective antibacterial treatment, as part of a timely and cautious management.

Market Segmentation

•  Drug Type Insights (Revenue, USD Mn, 2019 - 2031)
  • Oral & Parenteral Antibiotics
    • Oritavancin
    • Delafloxacin
    • Vancomycin
    • Others
  • Topical Antibiotics
    • Hydrogen Peroxide
    • Fusidic Acid
    • Mupirocin
    • Retapamulin
•  Infection Type Insights (Revenue, USD Mn, 2019 - 2031)
  • Hospital Acquired ABSSSI
  • Community Acquired ABSSSI
•  Route Of Administration Insights (Revenue, USD Mn, 2019 - 2031)
  • Oral
  • Parenteral
  • Topical
•  Distribution Channel Insights (Revenue, USD Mn, 2019 - 2031)
  • Hospital Pharmacies
  • Retail Pharmacies
  • Online Pharmacies
• Regional Insights (Revenue, USD Mn, 2019 - 2031)
  • North America
    • U.S.
    • Canada
  • Latin America
    • Brazil
    • Argentina
    • Mexico
    • Rest of Latin America
  • Europe
    • Germany
    • U.K.
    • Spain
    • France
    • Italy
    • Russia
    • Rest of Europe
  • Asia Pacific
    • China
    • India
    • Japan
    • Australia
    • South Korea
    • ASEAN
    • Rest of Asia Pacific
  • Middle East
    • GCC Countries
    • Israel
    • Rest of Middle East
  • Africa
    • South Africa
    • North Africa
    • Central Africa
• Key Players Insights
  • Fresenius SE & Co. KGaA
  • Pfizer, Inc.
  • Amneal Pharmaceuticals LLC
  • Intas Pharmaceuticals Ltd.
  • Cadila Healthcare Ltd.
  • Glenmark Pharmaceuticals Ltd
  • GSK plc
  • Sun Pharmaceutical Industries Ltd.
  • Aurobindo Pharma Ltd.
  • AbbVie, Inc.
  • Melinta Therapeutics LLC
  • Accord Healthcare Ltd.
  • Merck & Co., Inc.
  • Teva Pharmaceutical Industries Ltd.
  • Paratek Pharmaceuticals, Inc.