Lentiviral vectors are potential gene transfer vehicles used in both research and gene therapy applications. Lentiviral vectors are effective means of transferring genes because they can stably express a desired gene in non-diverging and diving cells. Lentiviral vectors are used for the treatment of various rare genetic disorders such as β-thalassemia, X-linked Adrenoleukodystrophy, X-linked severe combined immunodeficiency (SCID-X1), and Metachromatic Leukodystrophy. Lentiviral vectors derived from the human immunodeficiency virus (HIV-1) have become major tools for gene delivery in mammalian cells. The advantageous feature of lentivirus vectors is the ability to mediate potent transduction and stable expression in dividing and non-dividing cells both in vitro and in vivo. Lentiviruses have the unique ability among retroviruses of being able to infect non-cycling cells. Vectors derived from lentiviruses have provided a huge advancement in technology and seemingly offer the means to achieve significant levels of gene transfer in vivo. Lentiviral vectors (LV) are widely used in gene therapy and genome editing. Its manufacturing is progressing towards the use of stable producer cell lines, whether inducible or constitutive. Both stable cell lines are genetically engineered to suppress LV cytotoxicity, either temporarily or permanently. Moreover, various market players are focusing on increasing their research & development activities for gene therapies including lentiviral vectors, in order to enhance their product portfolio, which is expected to drive growth of the global lentiviral vectors market over the forecast period.
Market Dynamics
Market players are focusing on adopting various inorganic growth strategies, such as agreements, acquisitions, partnerships, and collaborations, in order to strengthen its market presence, which is expected to drive growth of the global lentiviral vectors market over the forecast period. For instance, on April 07, 2020, SIRION Biotech GmbH, a biotechnology company specializes in functional gene analysis, announced that it entered into an agreement with Beam Therapeutics, a biotechnology company, which is focusing on the use of CRISPR technology for the development of advanced genetic medicines. Under this agreement, SIRION Biotech GmbH provided the non-exclusive access of its proprietary lentiviral transduction enhancer LentiBOOST, to Beam Therapeutics for clinical development and commercialization of CAR-T programs.
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