Anhydrous dibasic calcium phosphate, also known as dicalcium phosphate, is produced by the neutralization of calcium hydroxide with phosphoric acid, which precipitates the dihydrate as a solid. At 60 °C, the anhydrous form is precipitated. The calcium phosphate salts can be anhydrous, meaning the water has been removed from the salt form. Other calcium phosphates are termed dibasic, meaning they have two replaceable hydrogen atoms. These are commonly used as diluents in the pharmaceutical industry. Diluents are added to pharmaceutical tablets or capsules to make the product large enough for swallowing and handling or more stable. Dibasic calcium phosphate is mainly used as a dietary supplement in prepared breakfast cereals, dog treats, enriched flour, and noodle products. It is also found in dietary calcium supplements. It is also used as poultry feed. It is also used in some toothpastes as a tartar control agent. Heating dicalcium phosphate gives dicalcium diphosphate, a useful polishing agent. Calcium phosphate dibasic is available in highly pure, submicron, and nanopowder forms, including military, reagent, technical (food, agricultural, and pharmaceutical grade); optical grade, united state pharmacopeia (USP), and EP/BP (European Pharmacopoeia/British Pharmacopoeia), and follows applicable American Society for Testing and Materials (ASTM) testing standards.
Market Dynamics
Increasing research & development activities by key market players is expected to drive the global anhydrous dibasic calcium phosphate market growth. For instance, according to an article published by the Journal Chemical Communications, on February 07, 2022, anhydrous calcium phosphate (CaP) crystals can stabilize DNA for dry storage. It has been investigated whether the structure and durability of DNA co-precipitated with CaP for dry storage can be enhanced. The enhanced stability of DNA in crystalline CaP was observed with powder X-ray diffraction (PXRD) including Rietveld refinement to identify phase compositions, scanning electron microscopy, (SEM), and infrared spectroscopy. This stabilizing effect is due to the structural change of CaP to monetite at 70 °C. The facile synthesis and drying procedures provide accessible tools for dense and stable room temperature storage of DNA. Our study shows the capability of salt-based storage solutions featuring high-loading, which further drives the technology towards automatized, long term preservation of digital data stored in DNA.
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