The biotech industry includes bio-pharma, bio-services, bio-agri, bio-industrials and bioinformatics. Biopharma is a rapidly growing segment that accounts for a dominant share in this sector. Advancements in biotechnology have enabled researchers to evaluate and identify target biomarkers/cell receptors to develop targeted and personalized therapies. Scientific research and technological advancements have resulted in the emergence of various personalized medicines that are undergoing research. According to research conducted by the Personalized Medicine Coalition, 42% of all compounds and 73% of oncology compounds in the pipeline possess the potential to be personalized medicine. Moreover, according to this study, it is expected that companies will increase their investment in R&D of personalized medicines by 1/3rd over the following five years. The study found that over 20% of drugs approved in 2014 were personalized medicines.

The biotechnology sector has witnessed some disruptive innovations such as gene and cell therapies, immunotherapy, and antibody drug conjugates. Advancement in stem cell therapy is resulting in effective treatment therapies for chronic conditions, organ growth and repair and disease prevention.

Key Challenges

Biotech products have extensive application in oncology and autoimmune disease treatment. However, the cost of these drugs is high owing to extensive research and trials that need to be carried out for the same. Therefore, there is constant pressure to reduce price and increase accessibility, especially in emerging economies. In the U.S., companies are facing reimbursement issues with respect to biopharmaceutical products. Besides, there are regulatory and scientific challenges faced by the sector. Scientific research for new molecules and targeted therapies is capital intensive and challenging owing to growing concern for safety of the drug.

Also, there is lack of awareness about personalized medicine among most healthcare providers, which may hamper its adoption. Clinical adoption of biotechnology products is essential for its success. However, it significant scientific evidence and backing is required to ensure its safety.

“Translating genomic discoveries into personalized medicines entails overcoming substantial scientific, regulatory, and economic challenges, including identifying validated biomarkers, as well as developing personalized therapeutics and clinically relevant diagnostic tests.”

Tufts Center for the Study of Drug Development

Opportunities

The biopharmaceutical sector offers vast lucrative growth opportunities. High efficacy and safety of biopharmaceutical products has led to a growth in their demand, Furthermore, consumers are willing to pay high prices for biopharmaceutical products compared to other conventional products. Biopharmaceutical brands have set new standards for blockbuster drugs by recording an annual average sale of over US$ 2bn. Drugs such as Humira have generated sales revenue of over US$ 10bn.

Governments in emerging economies are endorsing biosimilars as cost-effective alternatives to biotech products, which is expected to create significant growth opportunities for manufacturers of generic drugs. Therefore, cost-effectiveness and high quality are prime parameters that need to be considered while developing biosimilars. Recent and upcoming biologic patent expirations include the following:

Erbitux (cetuximab) - February 2016
Rituxan (rituximab) - September 2016
Herceptin (trastuzumab) - June 2019
Avastin (bevacizumab) - July 2019
Aranesp (darbepoetin alfa) - May 2024
Enbrel (etanercept) - November 2028

Companies such as Teva Pharmaceuticals, Hospira, Sandoz, and Amgen are focusing on development of biosimilars and vaccines as preventive measures in addition to treatment. For instance, in 2015, Zarxio TM became the first biosimilar to be approved in the U.S. market. The EMA approved Mosquirix, a malaria vaccine, in the same year. Extensive research is currently underway to develop a dengue vaccine, which could be another breakthrough pharmaceutical product in the near future.

Conclusion

The increasing research in the biotechnology sector is expected to result in higher number of biopharmaceutical products seeking FDA approvals. Biopharmaceuticals are positioned to be promising treatment solutions that would improve patient outcomes and help with reduction of the cost of drug development.View less

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Biotechnology Published Insights

Transfection Reagents And Equipment Market

Published Date : Apr 2023

Transfection is the process of introducing nucleic acids into eukaryotic cells by non-viral methods. The reagents and equipment used in these procedures are referred to as transfection reagents and equipment. Transfection has become the powerful analytical tool for th... View more

Molecular Cytogenetics Market

Published Date : Apr 2023

Molecular cytogenetics encompasses the combination of molecular biology and cytogenetics. Molecular cytogenetics includes all the aspects of chromosome biology with a wide range of applications in disease diagnosis and chromosomal abnormalities. It enables to differen... View more

Virus Filtration Market

Published Date : Apr 2023

Virus filtration is widely used to assure the viral safety of biopharmaceutical products. It is a size-based removal method which uses the polymeric membrane to retain virus particles on the surface and within the pores of the membrane. Virus filtration also helps to ... View more

Microneedle Flu Vaccine Market

Published Date : Mar 2023

Drug delivery through the skin using transdermal patches has always been effective against viral infections and influenza. Transdermal drug delivery is primarily efficient through passive drug diffusion followed by drug development of transdermal delivery systems thro... View more

Pediatric Vaccines Market

Published Date : Mar 2023

Immunizations is one of the public healthcare program for vaccination that prevents thousands of deaths, millions of cases of disease, and saves billions of dollars per decade. Immunizations are a safe, and effective way to protect children from disease including canc... View more

Ribonucleic Acid Rna Markers Market

Published Date : Mar 2023

A molecular marker (identified as genetic marker) is a fragment of DNA or RNA, which is associated with a certain location within the genome or RNA Pool. Molecular markers are used in molecular biology and biotechnology to identify a particular sequence of DNA or RNA ... View more

Cell Surface Markers Detection Market

Published Date : Mar 2023

Cell surface markers detection refers to separation and identification of target cells using analytical methods and processes, such as flow cytometry. Cell surface marker analysis through the usage of technologies, such as flow cytometry, is expected to simplify disea... View more

Mrna Synthesis Service Market

Published Date : Feb 2023

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Soft Tissue Repair Market

Published Date : Feb 2023

Soft tissue repair or healing is often referred to the sequential process by which damaged tissue is replaced with a living tissue and is further divided into three main categories: tissue repair, regeneration, and reconstruction. Soft tissue surgery is primarily aime... View more

Car T Cell Therapy Market

Published Date : Jan 2023

Chimeric antigen receptor (CAR)-T cell therapy is a type of immunotherapy which uses immune T cells to destroy cancer. CAR T cell therapy is also called as cell based gene therapy, as it involves gene altering in T cells. For chimeric antigen receptor (CAR)-T cell the... View more

Recombinant Protein Market

Published Date : Jan 2023

A recombinant protein is a protein encoded by recombinant DNA cloned into an expression vector that supports gene expression and translation of messenger RNA. Modification of genes by recombinant DNA techniques can result in the expression of mutant proteins. Recombin... View more

Biomarkers Market

Published Date : Jan 2023

A biomarker is a quantifiable sign of a biological condition or state. In order to investigate typical biological processes, pathogenic processes, or pharmacologic reactions to a therapeutic intervention, biomarkers are frequently examined and studied utilizing blood,... View more

Plasmid Dna Manufacturing Market

Published Date : Jan 2023

Circular double-stranded DNA present in the cytoplasm of a bacteria that replicate independently from the bacterial chromosome is called a plasmid DNA. Plasmids are small extra chromosomal DNA molecules within cells that are physically separated from the chromosomal ... View more

Bovine Plasma Market

Published Date : Jan 2023

Bovine plasma is extracted from animals belonging to the family Bovidae. This family includes not only cows but goats, sheep, bison and buffalo. Bovine plasma is the liquid component of the whole blood, which is free of cells and cellular debris. It is yellow in color... View more

Gmp Protein E Coli Contract Manufacturing Market

Published Date : Dec 2022

GMP Protein (E. coli) may or may not be manufactured using animal-free processes depending on the characteristics of the protein. Recombinant Protein is a protein encoded by a gene recombinant DNA that has been cloned in a system that supports the expression of ... View more

Pegylated Proteins Market

Published Date : Nov 2022

PEGylation is a process of addition of active polyethylene glycol (PEG) to different forms of therapeutic proteins for chemical modification. These chemically modified therapeutic proteins are called PEGylated protein therapeutics. PEGylated protein therapeutics are u... View more

Us Influenza Vaccines Market

Published Date : Nov 2022

Influenza is commonly referred as flu, a contagious respiratory illness which is caused by influenza virus. The virus can cause mild to severe illness, resulting in serious outcomes such as hospitalization or death. Geriatric population, pregnant women, and people wit... View more

Newborn Calf Serum Market

Published Date : Nov 2022

Newborn calf serum is the liquid portion of clotted blood taken from healthy, slaughtered bovine calves younger than 20 days that have been confirmed to be suitable for human consumption. It is widely used in industrial and academic research. It is one of the suppleme... View more

Biotechnology Published Insights

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