The biotech industry includes bio-pharma, bio-services, bio-agri, bio-industrials and bioinformatics. Biopharma is a rapidly growing segment that accounts for a dominant share in this sector. Advancements in biotechnology have enabled researchers to evaluate and identify target biomarkers/cell receptors to develop targeted and personalized therapies. Scientific research and technological advancements have resulted in the emergence of various personalized medicines... View more

The biotech industry includes bio-pharma, bio-services, bio-agri, bio-industrials and bioinformatics. Biopharma is a rapidly growing segment that accounts for a dominant share in this sector. Advancements in biotechnology have enabled researchers to evaluate and identify target biomarkers/cell receptors to develop targeted and personalized therapies. Scientific research and technological advancements have resulted in the emergence of various personalized medicines that are undergoing research. According to research conducted by the Personalized Medicine Coalition, 42% of all compounds and 73% of oncology compounds in the pipeline possess the potential to be personalized medicine. Moreover, according to this study, it is expected that companies will increase their investment in R&D of personalized medicines by 1/3rd over the following five years. The study found that over 20% of drugs approved in 2014 were personalized medicines.

The biotechnology sector has witnessed some disruptive innovations such as gene and cell therapies, immunotherapy, and antibody drug conjugates. Advancement in stem cell therapy is resulting in effective treatment therapies for chronic conditions, organ growth and repair and disease prevention.

Key Challenges

Biotech products have extensive application in oncology and autoimmune disease treatment. However, the cost of these drugs is high owing to extensive research and trials that need to be carried out for the same. Therefore, there is constant pressure to reduce price and increase accessibility, especially in emerging economies. In the U.S., companies are facing reimbursement issues with respect to biopharmaceutical products. Besides, there are regulatory and scientific challenges faced by the sector. Scientific research for new molecules and targeted therapies is capital intensive and challenging owing to growing concern for safety of the drug.

Also, there is lack of awareness about personalized medicine among most healthcare providers, which may hamper its adoption. Clinical adoption of biotechnology products is essential for its success. However, it significant scientific evidence and backing is required to ensure its safety.

“Translating genomic discoveries into personalized medicines entails overcoming substantial scientific, regulatory, and economic challenges, including identifying validated biomarkers, as well as developing personalized therapeutics and clinically relevant diagnostic tests.”

  • Tufts Center for the Study of Drug Development

Opportunities

The biopharmaceutical sector offers vast lucrative growth opportunities. High efficacy and safety of biopharmaceutical products has led to a growth in their demand, Furthermore, consumers are willing to pay high prices for biopharmaceutical products compared to other conventional products. Biopharmaceutical brands have set new standards for blockbuster drugs by recording an annual average sale of over US$ 2bn. Drugs such as Humira have generated sales revenue of over US$ 10bn.

Governments in emerging economies are endorsing biosimilars as cost-effective alternatives to biotech products, which is expected to create significant growth opportunities for manufacturers of generic drugs. Therefore, cost-effectiveness and high quality are prime parameters that need to be considered while developing biosimilars. Recent and upcoming biologic patent expirations include the following:

  • Erbitux (cetuximab) - February 2016
  • Rituxan (rituximab) - September 2016
  • Herceptin (trastuzumab) - June 2019
  • Avastin (bevacizumab) - July 2019
  • Aranesp (darbepoetin alfa) - May 2024
  • Enbrel (etanercept) - November 2028

Companies such as Teva Pharmaceuticals, Hospira, Sandoz, and Amgen are focusing on development of biosimilars and vaccines as preventive measures in addition to treatment. For instance, in 2015, Zarxio TM became the first biosimilar to be approved in the U.S. market. The EMA approved Mosquirix, a malaria vaccine, in the same year. Extensive research is currently underway to develop a dengue vaccine, which could be another breakthrough pharmaceutical product in the near future.

Conclusion

The increasing research in the biotechnology sector is expected to result in higher number of biopharmaceutical products seeking FDA approvals. Biopharmaceuticals are positioned to be promising treatment solutions that would improve patient outcomes and help with reduction of the cost of drug development.View less

Biotechnology Published Insights

Coherent Market Insights Epigenetics Drugs And Diagnostic Technologies Market

Published Date : Jul 2023

Gene mutations often result in the disruption of normal processing of genes and leads to the development of diseases. However, recently discovered epigenetic alterations have shown the potential to greatly influence tumoral response to therapy regimens. Such epigeneti... View more

Coherent Market Insights Lentiviral Vectors Market

Published Date : Jul 2023

Lentiviral vectors are potential gene transfer vehicles used in both research and gene therapy applications. Lentiviral vectors are effective means of transferring genes because they can stably express a desired gene in non-diverging and diving cells. Lentiviral vecto... View more

Coherent Market Insights Viral Vector And Plasmid Dna Testing Services Market

Published Date : Jul 2023

Testing services are crucial for the timely development of viral vector-based medicines since viral vectors are the best strategy for gene therapies. Characterization of the viral vector plays an essential role for orthogonal analytical methods. Through the regulatory... View more

Coherent Market Insights Us Vaccine Market

Published Date : Jul 2023

Vaccine is a biological component that promotes the formation of antibodies against various infections already present in the body. It is typically created utilizing pathogens and chemical medications that serve as antigens to ward off sickness. Conjugate vaccines, in... View more

Coherent Market Insights Cord Blood Banking Services Market

Published Date : Jul 2023

Cord blood banking is when a baby's umbilical cord blood is collected and stored after delivery. Cord blood is what's left inside a baby's umbilical cord after its cut. Umbilical cord blood is rich in stem cells. Stem cells are valuable because they help treat many li... View more

Coherent Market Insights Biotechnology Instruments Market

Published Date : Jun 2023

Biotechnology instruments are medical equipment used in biotechnology and the related field of medical engineering, focusing on the application of engineering tools for scientific discovery and for the diagnosis and treatment of various disease. Moreover, the advancem... View more

Coherent Market Insights Cell And Tissue Culture Supplies Market

Published Date : Jun 2023

Cell culture refers to removal of cells from an animal or plant and subsequent cultivation in an artificial environment for scientific research. Proper conditions should be provided for a cell to grow in lab. For this growth media is used, everything from the pH of th... View more

Coherent Market Insights Life Science Products Market

Published Date : Jun 2023

Life science, also referred to as biology, is the study of life and living things. It includes anatomy, animal biology, bacteriology, biochemistry, cell biology, ecology, evolutionary biology, genetics, molecular biology, plant biology, physiology, and virology. Life ... View more

Coherent Market Insights Europe Platelet Rich Plasma Market

Published Date : Jun 2023

Platelet-rich plasma consists of two elements: plasma, or the liquid portion of blood, and platelets, a type of blood cell that plays an important role in healing throughout the body. Platelets are well-known for their clotting abilities, but they also contain growth ... View more

Coherent Market Insights Dna And Rna Sample Preparation Market

Published Date : Jun 2023

A nucleic acid sample preparation is a process in which RNA and DNA is extracted and purified from biological samples that may contain tissue, blood, or other organic matter and prepare them for use.  For different research processes such as clinical and medical ... View more

Coherent Market Insights Gmp Cell Banking Services Market

Published Date : Jun 2023

Cell banking systems are set up to assure that a uniform population of cells is preserved, their integrity is maintained, and a sufficient supply of material is accessible for the life of the product. Biosafety testing is performed on cell lines at multiple passages.... View more

Coherent Market Insights Circulating Cell Free Tumor Dna Market

Published Date : Jun 2023

The term circulating tumor DNA (ctDNA) refers to DNA from malignant cells and tumors that circulate in the bloodstream. The nucleus of a cell contains most of the DNA. Cells die and are replaced by new ones as a tumor expands. The broken-down dead cells discharge thei... View more

Coherent Market Insights Biopharmaceuticals Market

Published Date : Jun 2023

A biopharmaceutical is a therapeutic drug manufactured in, extracted from, or semi-synthesized from biological sources. Biopharmaceuticals include a wide range of products such as vaccines, therapeutic proteins, blood and blood components, tissues, etc. Biopharmaceuti... View more

Coherent Market Insights Inactivated Polio And Rabies Vaccines Market

Published Date : Jun 2023

A vaccine consisting of inactivated poliovirus (IPV) types 1, 2, and 3, with active immunizing activity against poliomyelitis. Upon intramuscular vaccination, inactivated poliovirus vaccine (IPV) activates the immune system to develop antibodies against polio viruses.... View more

Coherent Market Insights Proteinase K Market

Published Date : May 2023

Proteinase K (also known as protease K or endopeptidase K) is a broad-spectrum serine protease widely used in molecular biology. Proteinase K can digest native keratin (hair), hence, the name “Proteinase K”. It is commonly used because of its broad specifi... View more

Coherent Market Insights Isothermal Nucleic Acid Amplification Technology Inaat Market

Published Date : May 2023

Isothermal nucleic acid amplification technologies have applications in the field of recombinant DNA and molecular biology techniques. These techniques are used in the detection and analysis of small quantity of nucleic acids. Polymerase chain reaction is based on iso... View more

Coherent Market Insights Antibodies Market

Published Date : Apr 2023

Antibodies are used in therapeutic applications for the treatment of diseases such as cancer, autoimmune diseases, hematological diseases, infectious diseases, and others. The increasing prevalence of cancer is expected to create lucrative opportunities for the growth... View more

Coherent Market Insights Stem Cell Cartilage Regeneration Market

Published Date : Apr 2023

In cartilage regeneration, stem cells have the potential for multiple differentiation and self-replication, making them an ideal choice for use as seed cells. The growing regenerative medicine industry and increasing demand for stem cells in the development of various... View more

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