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The biotech industry includes bio-pharma, bio-services, bio-agri, bio-industrials and bioinformatics. Biopharma is a rapidly growing segment that accounts for a dominant share in this sector. Advancements in biotechnology have enabled researchers to evaluate and identify target biomarkers/cell receptors to develop targeted and personalized therapies. Scientific research and technological advancements have resulted in the emergence of various personalized medicines... View more
The biotech industry includes bio-pharma, bio-services, bio-agri, bio-industrials and bioinformatics. Biopharma is a rapidly growing segment that accounts for a dominant share in this sector. Advancements in biotechnology have enabled researchers to evaluate and identify target biomarkers/cell receptors to develop targeted and personalized therapies. Scientific research and technological advancements have resulted in the emergence of various personalized medicines that are undergoing research. According to research conducted by the Personalized Medicine Coalition, 42% of all compounds and 73% of oncology compounds in the pipeline possess the potential to be personalized medicine. Moreover, according to this study, it is expected that companies will increase their investment in R&D of personalized medicines by 1/3rd over the following five years. The study found that over 20% of drugs approved in 2014 were personalized medicines.
The biotechnology sector has witnessed some disruptive innovations such as gene and cell therapies, immunotherapy, and antibody drug conjugates. Advancement in stem cell therapy is resulting in effective treatment therapies for chronic conditions, organ growth and repair and disease prevention.
Key Challenges
Biotech products have extensive application in oncology and autoimmune disease treatment. However, the cost of these drugs is high owing to extensive research and trials that need to be carried out for the same. Therefore, there is constant pressure to reduce price and increase accessibility, especially in emerging economies. In the U.S., companies are facing reimbursement issues with respect to biopharmaceutical products. Besides, there are regulatory and scientific challenges faced by the sector. Scientific research for new molecules and targeted therapies is capital intensive and challenging owing to growing concern for safety of the drug.
Also, there is lack of awareness about personalized medicine among most healthcare providers, which may hamper its adoption. Clinical adoption of biotechnology products is essential for its success. However, it significant scientific evidence and backing is required to ensure its safety.
“Translating genomic discoveries into personalized medicines entails overcoming substantial scientific, regulatory, and economic challenges, including identifying validated biomarkers, as well as developing personalized therapeutics and clinically relevant diagnostic tests.”
Opportunities
The biopharmaceutical sector offers vast lucrative growth opportunities. High efficacy and safety of biopharmaceutical products has led to a growth in their demand, Furthermore, consumers are willing to pay high prices for biopharmaceutical products compared to other conventional products. Biopharmaceutical brands have set new standards for blockbuster drugs by recording an annual average sale of over US$ 2bn. Drugs such as Humira have generated sales revenue of over US$ 10bn.
Governments in emerging economies are endorsing biosimilars as cost-effective alternatives to biotech products, which is expected to create significant growth opportunities for manufacturers of generic drugs. Therefore, cost-effectiveness and high quality are prime parameters that need to be considered while developing biosimilars. Recent and upcoming biologic patent expirations include the following:
Companies such as Teva Pharmaceuticals, Hospira, Sandoz, and Amgen are focusing on development of biosimilars and vaccines as preventive measures in addition to treatment. For instance, in 2015, Zarxio TM became the first biosimilar to be approved in the U.S. market. The EMA approved Mosquirix, a malaria vaccine, in the same year. Extensive research is currently underway to develop a dengue vaccine, which could be another breakthrough pharmaceutical product in the near future.
Conclusion
The increasing research in the biotechnology sector is expected to result in higher number of biopharmaceutical products seeking FDA approvals. Biopharmaceuticals are positioned to be promising treatment solutions that would improve patient outcomes and help with reduction of the cost of drug development.View less
Published Date : Sep 2023
Protein kinases play an important role in the catalytic activity and signaling functional transduction of critical cellular processes. TTK, also called monopolar spindle 1 (Mps1), is a dual specificity kinase that causes the phosphorylation of both tyrosine and serine... View more
Published Date : Sep 2023
Clustered regularly interspaced short palindromic repeats (CRISPR)-Cas9 is a unique technology that enables the geneticists and medical researchers to edit parts of the genome by removing, adding or altering sections of the deoxyribonucleic acids (DNA) ... View more
Published Date : Sep 2023
Nanobodies are engineered antibodies that have a single domain developed by heavy chains with antigen–binding. These antibodies can be engineered and are suitable for various applications for research, therapeutic development, and medical diagnosis due to their ... View more
Published Date : Sep 2023
Electrophoresis is a technique used in laboratory for separation of DNA, RNA, and protein molecules based on their size and electric charge. In this device, electric current is used for the separation of molecules from negative charge to positive charge. Smaller molec... View more
Published Date : Sep 2023
Tissue plasminogen activator (tPA) is an enzyme associated with the disintegration of blood clots. It is a serine protease present in endothelial cells. With the help of serine protease, the conversion of plasminogen to plasmin is catalyzed. Serine protease is a major... View more
Published Date : Sep 2023
Custom recombinant protein production is one of the efficient techniques used in life sciences that play a major role in advanced healthcare. Recombinant proteins have a wide range of applications in biotechnology, research, and medicine. Increasing funding in the fie... View more
Published Date : Sep 2023
According to the National Center for Biotechnology (NCBI), the human microbiota consists of 10-100 trillion symbiotic microbial cells, which is harbored by each person, this primarily includes bacteria in the gut. The human microbiome consists of the genes these micro... View more
Published Date : Sep 2023
Bacteriophage therapy has played a significant role in research fields of molecular biology and biotechnology since a long time. Phage-based treatment therapy is expected to emerge as a new treatment for managing persistent bacterial infections. These factors are wide... View more
Published Date : Sep 2023
DNA Chips, Biochips or DNA microarrays consists of a microscope slide made materials such as glass, silicon chips, and nylon membrane, which is printed with thousands of minute spots. These spots contain a known DNA sequence or gene in an orderly sequence. DNA microar... View more
Published Date : Aug 2023
Biological drugs refer to therapeutic products derived from living organisms or contain components of living organisms. Biological drugs are widely used in the treatment of number of diseases including diabetes, plaque psoriasis, arthritis, Crohn’s disease, and ... View more
Published Date : Aug 2023
Hematopoietic cell transplantation (also called bone marrow transplantation or stem cell transplantation) is a type of treatment for cancer (and a few other conditions as well). A review of the normal function of the bone marrow will help in the understanding of stem ... View more
Published Date : Aug 2023
The complex physiological process of bone formation and continuous remodeling of bone during fracture healing is known as bone regeneration. Bone regeneration is important in clinical conditions such as trauma-caused skeletal reconstruction, bone infection, tumor rese... View more
Published Date : Aug 2023
Stem cells are the body's raw materials—cells from which all other cells with specialized functions are generated. Under the right conditions in the body or a laboratory, stem cells divide to form more cells called daughter cells. These daughter cells become eit... View more
Published Date : Aug 2023
Sepsis is a condition wherein the body’s response to infection triggers an inflammation reaction throughout the body. The immune system releases inflammatory chemicals into the bloodstream to clear out pathogens from the body, but instead these chemicals cause a... View more
Published Date : Aug 2023
Cathepsin B is a cysteine protease found mainly in the lysosomes of normal cells but is secreted or associated with the plasma membrane of many transformed cells. It is found in all animals and other organisms and plays a key role in cellular protein metabolism. The c... View more
Published Date : Jul 2023
Cell therapy is the introduction of new cells into a patient’s body to grow, replace, or repair damaged tissue in order to treat a disease. A variety of different types of cells can be used in cell therapy, including stem cells, lymphocytes, and dendritic cells.... View more
Published Date : Jul 2023
Biotechnology uses living cells to develop or manipulate products for specific purposes. Early applications of biotech led to the development of products such as bread and vaccines. However, this discipline has evolved significantly over a period of time to manipulate... View more
Published Date : Jul 2023
The process of finding and analyzing single nucleotide polymorphisms (SNPs) in an individual's genetic material, such as DNA, is known as SNP genotyping. SNPs are the most prevalent technology of genetic variation identified in the human genome, and they consist of a ... View more
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