The biotech industry includes bio-pharma, bio-services, bio-agri, bio-industrials and bioinformatics. Biopharma is a rapidly growing segment that accounts for a dominant share in this sector. Advancements in biotechnology have enabled researchers to evaluate and identify target biomarkers/cell receptors to develop targeted and personalized therapies. Scientific research and technological advancements have resulted in the emergence of various personalized medicines... View more

The biotech industry includes bio-pharma, bio-services, bio-agri, bio-industrials and bioinformatics. Biopharma is a rapidly growing segment that accounts for a dominant share in this sector. Advancements in biotechnology have enabled researchers to evaluate and identify target biomarkers/cell receptors to develop targeted and personalized therapies. Scientific research and technological advancements have resulted in the emergence of various personalized medicines that are undergoing research. According to research conducted by the Personalized Medicine Coalition, 42% of all compounds and 73% of oncology compounds in the pipeline possess the potential to be personalized medicine. Moreover, according to this study, it is expected that companies will increase their investment in R&D of personalized medicines by 1/3rd over the following five years. The study found that over 20% of drugs approved in 2014 were personalized medicines.

The biotechnology sector has witnessed some disruptive innovations such as gene and cell therapies, immunotherapy, and antibody drug conjugates. Advancement in stem cell therapy is resulting in effective treatment therapies for chronic conditions, organ growth and repair and disease prevention.

Key Challenges

Biotech products have extensive application in oncology and autoimmune disease treatment. However, the cost of these drugs is high owing to extensive research and trials that need to be carried out for the same. Therefore, there is constant pressure to reduce price and increase accessibility, especially in emerging economies. In the U.S., companies are facing reimbursement issues with respect to biopharmaceutical products. Besides, there are regulatory and scientific challenges faced by the sector. Scientific research for new molecules and targeted therapies is capital intensive and challenging owing to growing concern for safety of the drug.

Also, there is lack of awareness about personalized medicine among most healthcare providers, which may hamper its adoption. Clinical adoption of biotechnology products is essential for its success. However, it significant scientific evidence and backing is required to ensure its safety.

“Translating genomic discoveries into personalized medicines entails overcoming substantial scientific, regulatory, and economic challenges, including identifying validated biomarkers, as well as developing personalized therapeutics and clinically relevant diagnostic tests.”

  • Tufts Center for the Study of Drug Development

Opportunities

The biopharmaceutical sector offers vast lucrative growth opportunities. High efficacy and safety of biopharmaceutical products has led to a growth in their demand, Furthermore, consumers are willing to pay high prices for biopharmaceutical products compared to other conventional products. Biopharmaceutical brands have set new standards for blockbuster drugs by recording an annual average sale of over US$ 2bn. Drugs such as Humira have generated sales revenue of over US$ 10bn.

Governments in emerging economies are endorsing biosimilars as cost-effective alternatives to biotech products, which is expected to create significant growth opportunities for manufacturers of generic drugs. Therefore, cost-effectiveness and high quality are prime parameters that need to be considered while developing biosimilars. Recent and upcoming biologic patent expirations include the following:

  • Erbitux (cetuximab) - February 2016
  • Rituxan (rituximab) - September 2016
  • Herceptin (trastuzumab) - June 2019
  • Avastin (bevacizumab) - July 2019
  • Aranesp (darbepoetin alfa) - May 2024
  • Enbrel (etanercept) - November 2028

Companies such as Teva Pharmaceuticals, Hospira, Sandoz, and Amgen are focusing on development of biosimilars and vaccines as preventive measures in addition to treatment. For instance, in 2015, Zarxio TM became the first biosimilar to be approved in the U.S. market. The EMA approved Mosquirix, a malaria vaccine, in the same year. Extensive research is currently underway to develop a dengue vaccine, which could be another breakthrough pharmaceutical product in the near future.

Conclusion

The increasing research in the biotechnology sector is expected to result in higher number of biopharmaceutical products seeking FDA approvals. Biopharmaceuticals are positioned to be promising treatment solutions that would improve patient outcomes and help with reduction of the cost of drug development.View less

Biotechnology Published Insights

Coherent Market Insights Pulmonary Surfactant Market

Published Date : Nov 2022

Pulmonary surfactant is a complex and highly surface active material composed of lipids and proteins which is found in the fluid lining the alveolar surface of the lungs. Surfactant plays a vital role in pulmonary physiology. It’s major biophysical functions is ... View more

Coherent Market Insights Clostridium Difficile Diagnostics Market

Published Date : Nov 2022

Clostridium difficile infection (CDI) is diagnosed with the help of conventional laboratory testing methods, however, rapid point-of-care diagnostic tests are also available, which can save time and costs significantly. Clostridium difficile is a disease caused by bac... View more

Coherent Market Insights Patient Temperature Monitoring Market

Published Date : Oct 2022

A temperature monitoring system regulates and controls the temperature of a particular environment. A patient temperature monitoring helps in measurement of the body temperature which helps in detection of the patient illness. The patient temperature monitoring is use... View more

Coherent Market Insights Human Embryonic Stem Cells Market

Published Date : Oct 2022

Stem cells are biological cells that can differentiate into other types of cells, and are used for therapeutic purposes. Recent developments or advancements have paved the way for a plethora of potential therapies, due to which, therapies involving human embryonic ste... View more

Coherent Market Insights Glycobiology Market

Published Date : Oct 2022

Glycobiology is the branch of science which deals with the study of Glycan and glycan-modified biomolecules such as glycolipids, glycoproteins and glycosylated small molecules collectively referred to as sugar molecules. Glycan are universal in all aspects of life. Th... View more

Coherent Market Insights Biophotonics Market

Published Date : Sep 2022

Biophotonics refers to the combination of field of photonics and biology. It is a light-based technology used in medicine and life-science for generation, detection of photons, manipulation, and quantum units of lights. This technology is also used in the study of the... View more

Coherent Market Insights Conjugate Vaccine Market

Published Date : Sep 2022

Conjugate vaccine is a combination of a weak antigen with a strong antigen so as to provide active immunization against immune system having a stronger response to the weak antigen. In a conjugate vaccine, the weak antigen is covalently attached to a strong antigen an... View more

Coherent Market Insights Tissue Banking Market

Published Date : Sep 2022

Tissue banks recover, process, store, and distribute tissue for transplantation. Research in the field of tissue preservation at low temperature and high clinical success of transplanted tissue led to increase in the use of stored tissue in major burn and trauma patie... View more

Coherent Market Insights Immune Checkpoint Inhibitors Market

Published Date : Aug 2022

Immune checkpoint inhibitors are a part of immuno-oncology therapies, which involves use of patients’ immune system to fight against cancer. Immuno-oncology uses novel immunotherapies such as immune checkpoint inhibitors that boost the immune system of patients.... View more

Coherent Market Insights Typhoid Fever Vaccines Market

Published Date : Aug 2022

Typhoid fever is a bacterial infection caused by Salmonella typhi, which causes symptoms such as prolonged fever, headache, nausea, loss of appetite, and constipation or sometimes diarrhea. The bacterium usually enters the body through the mouth by the ingestion of co... View more

Coherent Market Insights Low Molecular Weight Heparin Market

Published Date : Aug 2022

Low Molecular Weight Heparins (LMWH) are a form of pharmacological anticoagulant intervention which are derived from unfractionated heparin (UFH) by chemical or enzymatic depolymerisation to yield fragments that are around one third the size of heparin.  Low mole... View more

Coherent Market Insights Human Recombinant Insulin Market

Published Date : Jul 2022

Recombinant human insulin is the synthetic insulin, developed using recombinant DNA technology by growing insulin proteins within Escherichia coli. Recombinant human insulin has a faster onset of action and lower immunogenicity than other types of insulin such as pork... View more

Coherent Market Insights Cell Lysis Market

Published Date : Jul 2022

Cells contain biomolecules such as proteins or nucleic acids present in the cytoplasm and enclosed within a membrane. Cell lysis is a process in which a cell membrane is ruptured due to some external forces or conditions such as viral infection or osmosis, resulting i... View more

Coherent Market Insights Recombinant Vaccine Market

Published Date : Jun 2022

Recombinant vaccines are products of genetic engineering, in which a harmless agent, such as yeast, is programmed to produce antigens of diseases. A small piece of DNA is extracted from the virus or bacteria against which protection is required and inserted into the m... View more

Coherent Market Insights Asia Pacific Wound Care Biologics Market

Published Date : Jun 2022

Wound care biologics are bioengineered products used for non-healing wounds of the lower extremity. Wound care biologic dressings are increasingly used in post surgeries and severe trauma cases, as they provide a moist healing environment aiding heat, protein, and ele... View more

Coherent Market Insights Rhu Albumin Market

Published Date : Jun 2022

A biopharmaceutical is a medicinal product that is derived from biological sources such as animals, humans, and microorganisms using biotechnology. They are manufactured using stem cells, mammalian cells, etc., through tissue culture methods. ... View more

Coherent Market Insights Middle East And Asia Pacific Cell And Gene Therapy Market

Published Date : Mar 2022

Cell therapy is the administration of living cells in patients for the treatment of a disease such as oncology, Immunology and others. The source of a cell can be autologous or allogeneic, which can be derived from stem cells such as bone marrow. Stem cells therapy is... View more

Coherent Market Insights Covid 19 Sample Collection Kits Market

Published Date : Mar 2022

Coronavirus disease is a contagious disease caused by severe acute respiratory syndrome (SARS-CoV-2). COVID-19 sample collection kits are the kits that consist of reagents and consumables for facilitating the detection and diagnosis of SARS-Cov2 infection from nasal, ... View more

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