The prolonged usage of over-the-counter pain medications can lead to several side effects in individuals. Constant intake of medicines containing pain relievers like ibuprofen and acetaminophen over long periods can cause gastrointestinal issues like acidity, ulcers, and intestinal bleeding. Prolonged dependence on such medications for minor aches and pains may damage the kidneys and liver with excessive and regular usage beyond the recommended duration. This can seriously impact the health of consumers in the long run. Such potential health risks associated with side effects are restraining many customers from frequent and continuous reliance on over-the-counter pain relief options. Several studies and reports from international health organizations have highlighted the risks of opioid dependence and addiction with prolonged intake of medications containing codeine and other opioid compounds. For instance, according to the 2021 report from the World Health Organization, nearly 33% of people who were prescribed opioid drugs for chronic non-cancer pain or injury misused them within a year. This led to 2.1 million opioid use disorders globally. The risks of dependence and addiction have made consumers wary of continuously using OTC medications containing codeine, impacting repeat purchases and overall market growth. Awareness of side effects is prompting consumers to seek alternative treatments like physical therapy, acupuncture, or topical creams to manage minor pains. This shift is gradually shrinking the customer base for OTC pain relief products in the long-run, especially if stringent safety checks are not implemented. To sustain growth, companies are investing in R&D to develop safer formulations with reduced risks of side effects and launching public health campaigns to educate proper usage. However, the negative perception around side effects continues to restraint the market.
Market Opportunities: Advancements in drug delivery systems
Advancements in drug delivery systems promise to be a great opportunity for the global over-the-counter pain medication market. Conventional drug delivery methods often experience limitations such as ineffective drug levels at target sites, numerous daily dosages, and lack of patient compliance. The development of novel drug delivery carriers and platforms can help overcome many of these limitations. Controlled and targeted delivery systems allow medications to be released gradually at predetermined rates, maintaining consistent therapeutic drug concentrations at disease sites over an extended period of time. This reduces dosage frequency and improves patient compliance. For example, transdermal drug delivery systems use adhesive patches to deliver pain relieving gels or creams through the skin directly into the bloodstream at a controlled rate for up to 3 days, eliminating the need for multiple daily oral doses. Similarly, polymer-based microsphere and nanoparticle carriers protect drugs from degradation and ensure steady release of encapsulated medications for prolonged pain relief with fewer administrations. Advanced delivery platforms are also working towards improving targeting ability. Stimuli-responsive "smart" drug carriers that are triggered by physical factors like temperature, pH or enzymes present in specific organs can preferentially release higher doses of medication only at sites of pain or inflammation. This enhances therapeutic effects and minimizes adverse reactions. According to a 2021 report by the World Health Organization, targeted drug delivery may help address the global problem of inadequate access to pain treatment, especially in low and middle-income countries.
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