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Increasing usage in agriculture industry
The agriculture industry worldwide has relied on heterocyclic and fluorinated agrochemicals such as pesticides, herbicides, and fungicides to boost crop yields for many decades. Chloro and fluoro substituted heterocyclic compounds are widely employed as active ingredients in various agrochemical formulations due to their potency and ability to control pests, weeds, and fungal infections selectively. However, factors such as the emergence of resistance in pests, stringent environmental regulations, and need for higher crop protection are driving agrochemical companies to come up with newer heterocyclic chemistries and optimized fluorinated molecules.
Research indicates that focused library screening programs involving heterocyclic scaffolds effectively deliver novel lead structures with enhanced activity against target pests. For instance, new fungicides based on heterocyclic chemotypes are showing great potential against phytopathogenic fungi that are resistant to earlier generations of agrochemicals. Meanwhile, the addition of fluorine substituents to agrochemical cores improves their chemical and metabolic stability, thereby enabling lower application dosages and reducing residue levels in food crops. This helps agrochemical product developers comply with maximum residue limit regulations.
Considering the projections for global population growth and rising demand for food grains, agriculture outputs need to be significantly scaled up in the coming years. This will spur further innovation in agrochemical formulations relying on heterocyclic and fluorinated active ingredients to address challenges facing modern agriculture. Over the long term, the widespread adoption of integrated pest management practices can also stimulate the diversified demand for heterocyclic and fluorinated compounds meeting stringent safety standards for sustainable crop protection.
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