GLOBAL OPTICAL GENOME MAPPING MARKET SIZE AND SHARE ANALYSIS - GROWTH TRENDS AND FORECASTS (2023-2030)

The global optical genome mapping market size is expected to reach US$ 418.4 Mn by 2030, from US$ 109.9 Mn in 2023, exhibiting a compound annual growth rate (CAGR) of 21% during the forecast period.

Optical genome mapping is an emerging technique that uses optimized optical microscopy to map entire genomes at the single-cell level. This allows the mapping of structural variations in genomes with higher resolution and precision compared to other techniques like next-generation sequencing. Optical mapping helps map megabase-sized structural variations like inversions, translocations, and large deletions/insertions. With declining costs of genome sequencing, optical mapping is finding increasing applications in genomics research and precision medicine by assisting in genome assembly, structural variation detection, pathogen identification, and disease research.   

Global Optical Genome Mapping Market- Regional Insights

• North America is expected to be the largest market for optical genome mapping during the forecast period, accounting for over 35.7% of the market share in 2023. The optical genome mapping market in North America is driven by rising geriatric population susceptible to genetic disorders, growing applications of genome analysis in oncology, and increasing funding for genome research projects.
• Asia Pacific is expected to be the second-largest market for optical genome mapping, accounting for over 25.2% of the market share in 2023. The optical genome mapping market in Asia Pacific is experiencing positive growth owing to several factors. The rising incidence of genetic disorders and chronic diseases, such as cancer, is a key factor fueling the demand for advanced genomic analysis techniques such as optical genome mapping.
• Europe is expected to be the fastest-growing market for optical genome mapping, with a share of 19.0% during the forecast period. The optical genome mapping market in Europe is driven by the growing focus on precision medicine, companion diagnostics, and advancements in genome analysis techniques.

Figure 1. Global Optical Genome Mapping Market Share (%), By Region, 2023

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Analyst’s Views: The global optical genome mapping market has strong growth potential driven by advancements in genomics and sequencing technologies. Optical genome mapping helps in rapid and accurate whole genome analysis without amplification which is useful for research in human diseases and personalized medicine. The major drivers for market growth are increased application in genetic disorders, cancer research, and technological advancement offering high resolution genome images at lower cost. However, regulations associated with genomic data handling and lack of skilled professionals pose challenges.

Global Optical Genome Mapping Market- Drivers

• Genome mapping applications: Genome mapping applications have significantly boosted the global optical genome mapping market in recent years. Optical genome mapping provides a comprehensive overview of the structure and organization of genomes. It allows researchers to visualize entire genomes at a much higher resolution compared to traditional sequencing methods. This has enabled new discoveries in basic biology, disease research, and precision medicine. Optical genome mapping is being extensively used by pharmaceutical and biotechnology companies for preclinical drug development and clinical trial design. It helps in targeted therapy development by aiding in the identification of genetic variants associated with diseases.
• Next-generation sequencing: Next-generation sequencing technologies are revolutionizing the field of genomics and enabling faster and more comprehensive analysis of genomes at reduced costs. For instance, the article titled "Optical Genome Mapping as a Next-Generation Cytogenomic Tool for Detection of Structural and Copy Number Variations for Prenatal Genomic Analyses" that appeared in Gene's journal in 2021 addresses that OGM-based assays are automated, low-cost, and have a short turnaround time (from sample to report in 4 days). They also do not require complex custom bioinformatic pipelines and are high-resolution in comparison to traditional methods.
• Genetic disorder diagnosis: The diagnosis of genetic disorders is being revolutionized by optical genome mapping technology, driving significant growth of the global optical genome mapping market. Optical genome mapping provides a fast and comprehensive way to see the whole genome and identify chromosomal abnormalities, enabling more accurate diagnosis of conditions caused by structural variations. This is hugely important as structural variations like duplications and deletions that cannot be detected by traditional sequencing, underlie a wide range of genetic disorders.

Global Optical Genome Mapping Market- Opportunities

• Genome mapping for cancer research: Genome mapping for cancer research presents a major opportunity in the global optical genome mapping As genome mapping allows a comprehensive analysis of the entire genome in one go, it is emerging as a powerful tool for cancer research. For instance, in August 2021, according to a study published in ScienceDirect journal, optical genome mapping resulted in a more complete assessment than any previous single test and most likely reported the most accurate underlying genomic architecture (e.g., for complex translocations, chromoanagenesis, and marker chromosomes). In conclusion, the excellent concordance of OGM with diagnostic standard assays demonstrates its potential to replace classical cytogenetic tests as well as to rapidly map novel leukemia drivers.
• Advent of targeted therapeutics: The advent of targeted therapeutics can unlock immense opportunities in the global optical genome mapping market. Targeted therapeutics allows for the precise targeting of diseases at the genetic level. With optical genome mapping, one can gain a comprehensive understanding of a person's entire genome and epigenome at an unprecedented scale and resolution. This detailed genomic information paves the way for the development of innovative targeted therapeutics that can address diseases with much higher specificity and efficacy.
• Integration with other omics technologies: Integration with other omics technologies offers immense opportunities for the optical genome mapping market. Optical genome mapping, when combined with technologies like genomics, epigenomics and transcriptomics, provides a more comprehensive understanding of the genome. This integrated approach allows researchers to study how genetic variations correlate with gene expressions and activities, leading to insights into disease mechanisms. Optical genome maps, by incorporating structural variations data, complement DNA or RNA sequence information. They can help resolve complex genomic regions that still remain ambiguous even after high-coverage sequencing.

Global Optical Genome Mapping Market- Trends

• Advancements in sequencing technologies: Advancements in sequencing technologies have greatly influenced the global optical genome mapping market in recent years. Next generation sequencing technologies have significantly brought down the cost of decoding the entire genome. While whole genome sequencing provides nucleotide-level resolution, it does not reliably capture large structural variants which plays an important role in genetic disorders and complex diseases. Optical genome mapping helps address this limitation as it can rapidly analyze entire genomes to detect large structural changes like insertions, deletions, inversions, and translocations at a relatively lower resolution compared to sequencing.
• Adoption of cloud-based analysis solutions: The adoption of cloud-based analysis solutions is having a significant impact on the global optical genome mapping market. As researchers and healthcare organizations now have the ability to easily access advanced genome mapping and analysis technologies via the cloud without having to make large upfront investments in infrastructure and hardware. This has increased the accessibility of optical genome mapping solutions and driven more organizations, especially smaller labs and research facilities, to utilize these technologies for their work. Cloud-based platforms are allowing for faster, more collaborative analysis of large genomic datasets through their powerful computing capabilities and ability to handle large storage needs.

Global Optical Genome Mapping Market - Restraints

• High cost of instruments: The high cost of instruments used for optical genome mapping is one of the major factors restraining the growth of the global optical genome mapping market. Optical genome mapping involves the use of sophisticated laboratory equipment and instruments for mapping and analyzing genomes at a much larger scale. These instruments, such as DNA nicking and labeling instruments, DNA stretching system, DNA alignment and mapping systems, imaging systems, etc. are extremely expensive and cost upwards of hundreds of thousands of dollars. While this high-end technology provides highly accurate, detailed and efficient genome mapping unlike traditional methods, the steep capital investment required poses a significant challenge, especially for small to medium scale clinical laboratories and research institutes in developing nations.
• Regulatory and ethical barriers: Regulatory and ethical barriers are imposing significant restraints on the growth of the global optical genome mapping market. Optical genome mapping being an advanced genomic technique involves handling highly sensitive genomic data. Various countries have stringent regulations around ethical and legal use of genomic data to protect patient privacy and prevent misuse. Complying with different regulatory frameworks across countries requires extensive validation and documentation which increases the cost and complexity for market players. Also, optical genome mapping is currently used majorly for research purposes involving human samples. Any non-consented use of human samples or genetic data for commercial applications is a serious ethical concern.

Figure 2. Global Optical Genome Mapping Market Share (%), By End User, 2023

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Global Optical Genome Mapping Market- Recent Developments

Product and Technology Launch

• On June 29, 203, Bionano Genomics, Inc., a genome analysis company, announced the Stratys system for high throughput optical genome mapping (OGM) and VIA software for the visualization, interpretation, and reporting of genome analysis for OGM, microarrays, and next-generation sequencing (NGS) data in one integrated software platform.
• On January 23, 2023, Bionano Genomics, Inc. announced the launch of multiple new products and advancements for its optical genome mapping (OGM) workflow that offers enhanced robustness in sample preparation, decreased turnaround time for DNA labeling and imaging, and improvements in throughput and quality metrics. The new versions of company’s sample prep kits, chips, and instrument software address customer feedback and can improve the performance in routine higher volume genome analysis applications.
• In June 2022, Arima Genomics, a biotechnology company, introduced two new product lines, the Arima-HiC+ FFPE kit, which allows scientists to use this technology to identify structural variants in their 3D genomic data. Researchers will learn more about the effects of variations on gene and cellular function by fusing structural variant detection with 3D genome orientation data.

Business Development Activities by the Market Players

• In November 2022, Bionano Genomics, Inc. announced that it had entered into a definitive agreement to acquire Purigen Biosystems, Inc., a company that develops and commercializes automated nucleic acid extraction and purification solutions using proprietary isotachophoresis (ITP) technology, which was licensed exclusively from Stanford and developed by Purigen Biosystems, a biotechnology company. The transaction was expected to accelerate the adoption of OGM due to anticipated improvements in its ultra-high molecular weight (UHMW) DNA sample preparation workflow.
• In October 2021, Bionano Genomics, Inc. announced its US$100 million acquisition of BioDiscovery Inc., a software company specializing in genomics data. This acquisition grants it access to BioDiscovery Inc.’s Nx Clinical software, which the company plans to integrate into its optical genome mapping (OGM) software.

Top Companies in the Global Optical Genome Mapping Market

• Bionano Genomics
• Nucleome Informatics Private Limited
• Praxis Genomics, LLC
• SourceBio International Limited (Source BioScience)
• MedGenome
• INRAE (French Plant Genomic Resources Center (CNRGV))
• PerkinElmer (PerkinElmer Genomics)
• Genohub Inc.
• Hofkens Lab
• Cerba

Definition: Optical Genome Mapping (OGM) is a technology used to obtain high-resolution, comprehensive structural variation of genomes. Unlike traditional sequencing methods that read small segments of DNA at a time, optical genome mapping involves imaging long strands of DNA to identify structural variants—such as insertions, deletions, translocations, inversions, and copy number variations—with a high degree of accuracy.