Side effects of existing non-opioid drugs is posing major challenges for the growth of non-opioid pain treatment market. NSAIDs, which are the most common form of non-opioid painkillers available, are associated with increased risk of gastrointestinal, kidney and cardiovascular side effects on long term use. NSAIDs can cause issues like gastritis, ulcers and in severe cases gastrointestinal bleeding. These also exacerbate existing kidney problems in many individuals. Long term use of some NSAIDs has been linked to increased chance of cardiovascular diseases like heart attacks and strokes, according to the data from the National Center for Biotechnology Information published in October 2020.
Market Opportunities - Combining non opioid treatment approaches
Postoperative and cancer pain management remain two areas that present major unmet needs in pain treatment. At the same time, pain is one of the most common and distressing symptoms experienced by cancer patients, with over 90% of advanced stage cancer patients battling pain. However, opioid treatment continues to be the standard of care for managing both postoperative and cancer pain despite the growing crisis of opioid addiction and overdose deaths. This presents a massive opportunity for non-opioid pain therapies to take the lead in treating these underserved patient populations.
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