Market Challenges And Opportunities
Global Long Read Sequencing Market- Drivers
- Increasing applications in DNA sequencing: Increasing applications of DNA sequencing in various fields such as precision medicine, genomics research, and diagnostics of genetic diseases is one of the major factors fueling the growth of global long read sequencing market. Long read sequencing allows analysis of entire genomes and full-length transcripts, which provides valuable insights for research in complex genomes, transcriptomes, epigenomes, and metagenomes.
- Increasing funding and investments: Global long read sequencing market is experiencing significant growth due to rising investments and funding in this domain over the recent years. Long read sequencing allows scientists to view complete gene sequences or read extremely long strings of deoxyribonucleic acid (DNA)/ ribonucleic acid (RNA) bases. This vast genomic information provided by long read sequencing is revolutionizing the fields of genomics, clinical diagnosis and disease research. For instance, in 2020, Ms. Maizie (Xin) Zhou, assistant professor of biomedical engineering and computer science, is the recipient of a US$1.9 million award from the National Institutes of Health. She has also received US$120,000 from Complete Genomics, a leader in human genome sequencing.
Global Long Read Sequencing Market- Opportunities
- Potential applications in clinical diagnosis and precision medicine: Long read sequencing has exciting applications in clinical diagnosis that could drive significant growth in this market. One of the greatest challenges in diagnosis has been identifying structural variants like insertions, deletions, and rearrangements that are difficult to detect with short read technologies. Long reads allow researchers to assemble complete genomes and detect these variants with high accuracy. This will enable more precise diagnosis of genetic diseases and disorders. For example, long reads have helped identify the genetic causes of certain types of epilepsy and dementia that were previously unknown. With improvement in genetics, long read sequencing will be pivotal in analyzing the full spectrum of variants contributing to many conditions. This new diagnostic capability could revolutionize personalized treatment approaches.
Global Long Read Sequencing Market - Restraints
- Complex data analysis of long reads: The high complexity involved in the analysis of long read sequencing data has emerged as a major bottleneck restricting the widespread adoption and growth of this promising technology. Long read sequencing can generate reads that are 10-100x longer than short read technologies. However, aligning and assembling these long reads poses considerable computational and bioinformatics challenges. Unlike short reads which can be easily mapped to reference genomes, long reads due to their large size cannot be accurately aligned and analyzed by using conventional short read assembly tools. Developing customized algorithms and infrastructure capable of handling gigabytes to terabytes of complex sequencing data from a single long read run is still a work in progress. This has made it difficult for many smaller labs and institutions without access to high performance computing capability to fully utilize the potential of long read sequencing.
Counterbalance: To overcome this restraint, it is needed to develop customized algorithms and infrastructure which is capable of handling gigabytes to terabytes of complex sequencing data from a single long read run.
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