Global Acute Dystonia Market - Drivers
Increasing prevalence of dystonia: The incidence and prevalence of dystonia is on the rise globally. As per various studies and research, dystonia is more common than previously thought with an estimated prevalence of 17.6 per 100,000 people worldwide. The condition is also known to be under-diagnosed in many parts of the world. With growing awareness about different types of dystonia among medical professionals as well as general public, more cases are being identified and reported.
The ageing population across the developed world has also contributed to the increasing prevalence of dystonia. Since dystonia is more likely to develop in older individuals, countries with larger elderly population cohorts have witnessed higher dystonia patient numbers. Rising life expectancy worldwide indicates that the percentage of people struggling with age-related medical issues including dystonia will continue expanding in the future. Additionally, factors like better diagnosis and documentation have made many historic or undiagnosed dystonia cases visible now.
The growing dystonia patient pool is expected to significantly drive the demand for effective treatment options and acute dystonia management drugs. With more dystonia types and subtypes being identified, the market is also witnessing demand for condition-specific drug therapies. Currently available generic drugs may not fully address all manifestations of dystonia phenotypes. This unmet need opens up opportunities for novel drug research and development by pharmaceutical players.
Advancing research on etiology and new drug targets: Considerable research efforts are ongoing in the field of dystonia with focus on improving understanding of underlying pathology and identifying new therapeutic areas. While several causative genetic flaws and likely biochemical irregularities have been linked to certain dystonia types, exact reasons for development and progression of the condition remain ambiguous in majority of cases.
Continued molecular level investigation of dystonia has the potential to uncover novel biological pathways and targets for acute as well as long-term symptomatic relief. Promising areas that are under active study include role of Basal Ganglia circuits, disturbed Dopamine-GABA signaling in the brain, neurological signaling abnormalities triggered by genetic mutations. Advancing knowledge about dystonia etiology can facilitate the creation of precision medicines and assist researchers in repurposing existing drugs for off-label dystonia applications.
In addition, non-dopaminergic treatments are being explored as current therapy options centered around Dopamine agonists have limited efficacy in many patients and produce undesirable side effects. Newer drug classes in preclinical/clinical trial phases include GABA enhancers, glutamate blockers, histone deacetylase inhibitors, and others. Successful research outcomes indicating the safety and effectiveness of investigational compounds can stimulate the demand for improved pharmaceutical interventions apart from standard drug formulations.
The growing research and development focus on novel drug targets and precision therapies presents potential growth opportunities for the acute dystonia market. It may also help address currently unmet needs of subsets of dystonia patients not benefitting from first line medications. This ongoing research renaissance can potentially expand the arsenal of acute dystonia management solutions available to medical community and patients.
Global Acute Dystonia Market - Opportunity
Global Acute Dystonia Market - Restraints
Global Acute Dystonia Market Report Snapshots
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