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Advancing Bioprocessing Technologies
With the biopharmaceutical industry continually expanding, so too are the demands on downstream processing. As therapeutic monoclonal antibody and recombinant protein production increases in scale and complexity, manufacturers require more sophisticated methods for recovery, purification and formulation. New technologies that improve yields, throughput and product quality are high priorities. Continuous manufacturing platforms allow for real-time monitoring and control across separation, filtration and chromatography steps. This brings increased process understanding and flexibility compared to traditional batch operations. Membrane adsorbers are gaining favor for their ability to consolidate multiple unit operations into single-use cassettes. Their effectiveness at capturing targets from crude feedstocks while allowing rapid, scalable elution assists in meeting tight timelines. Looking further ahead, integrated modular systems incorporating multiple separation technologies promise to automate downstream workflows from start to finish. If successful in demonstrating reliable performance at commercial biomanufacturing scales, such integrated solutions could help facilities boost productivity and reduce unit costs by streamlining changeovers between campaigns.
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