Stem cells are disrupting the drug discovery and development landscape. They offer more accurate and efficient platforms for testing new pharmaceuticals. These cells are being widely used in new and innovative ways to enhance the drug discovery process.
Traditional drug discovery methods like animal testing do not always accurately mimic human physiology. On the other hand, stem cell-derived models provide a more precise, scalable, and cost-effective alternative.
Can the usage of stem cells in drug discovery impact their demand? The statistics suggest so. Adoption of stem cells in drug discovery and development is set to provide an additional boost to the industry. According to Coherent Market Insights, the global stem cells industry is set to grow at 9.1% CAGR, reaching US$ 23.7 billion by 2030.
Disease Modeling
The first and foremost contribution of stem cells is their tendency to model human diseases in vitro. The disease modeling approach enables a better understanding of diseases at the cellular level. By doing this, it aids in the identification and validation of potential drug targets.
Scientists obtain stem cells from patients and then reprogram them into specific cell types affected by a particular disease. The new induced pluripotent stem cell (iPSCs) allows researchers to understand disease mechanisms in a controlled laboratory setting. These models are proving helpful for treating diseases like neurodegenerative disorders and cancer.
High Throughput Screening
Stem cell-derived models are employed for high-throughput screening of large drug libraries to identify potential candidates. This approach is more efficient and cost-effective than traditional methods.
Traditional drug screening techniques often fail to fully replicate human physiology. As a result, novel approaches like stem-cell models are getting into the spotlight.
Stem cells can be differentiated into human-specific cell types like hepatocytes, cardiomyocytes, and neurons. These cells are then employed in high throughput screening to assess thousands of drug candidates simultaneously.
Target Identification
Stem cells are become ideal tools in target identification for drug discovery and disease treatment. This is because of their tendency to mimic human physiological conditions.
Stem cell-based models allow for a faster, cheaper, and more accurate way to investigate novel disease mechanisms. By doing this, they offer a holistic and empirical approach to identifying novel compounds that revert disease-associated phenotypes.
Stem cell-derived models can mimic human physiology more accurately than conventional models like animal studies and 2D cell cultures. This makes them perfect for testing novel compounds.
Scientists and researchers across the globe are becoming aware about the benefits of drug testing with stem cells, leading to their increased usage. In the future, we may see frequent usage of stem cells in vaccine development.
Toxicity Screening
A prominent cause of failure during clinical trials is drug toxicity. Stem cells offer an effective solution to address this challenge.
Stem cells can play a significant role in toxicity testing. They have the tendency to assess the toxicity of potential drug candidates. For instance, iPCS-based cardiomyocytes are often utilized to assess the cardiotoxicity of drug candidates.
Stem cells are becoming incredibly useful tools for identifying off-target adverse effects of drugs already in development. There are several stem cell-derived toxicity screens available that have been shown to work by identifying side-effects of drugs. Identifying side effects early in the drug development pipelines can also be much more cost-effective than detecting them later.
Stem cells empower scientists to detect potential side effects. They also allow them to assess drug safety before entering clinical trials and reduce the risk of adverse effects in human patients. Growing adoption of stem cells for toxicology studies is expected to play a key role in boosting the global industry.
Personalized Medicine
Stem cells are at the heart of personalized medicine. Thanks to patient-specific stem cells, researchers can identify the most effective and safer treatments for each individual.
Stem cell-derived models have the tendency to revolutionize treatment of complex diseases like cancer and neurodegenerative disorders. They allow for development of tailored treatments with optimal efficacy and minimal side effects.
