PD-1 is a checkpoint protein on immune cells that are known as T cells. It normally acts as a type of off switch which help from the T cells attacking other cells present in the body. This action is performed when it attaches to PD-L1, which is a protein on some normal (and cancer) cells.
As of 2021, the global PD-1 and PD-L1 Inhibitor Market was valued at US$ 30,535.5 Million and is expected to reach a value of US$ 77,541.1 Million by 2028 at a CAGR of 14.2% between 2022 and 2028.
Prominent Companies in the PD-1 and PD-L1 Inhibitor Industry:
1) Novartis AG
Novartis AG is a Swiss pharmaceutical corporation founded in March 1996 by Johann Rudolf The headquarters are located in Basel Switzerland, Cambridge, The United States of America and Massachusetts. It is one of the largest Pharma based company incorporated. The drugs manufactured are sold worldwide.
In June, 2022 Novartis completed the acquisition of Kedalion Therapeutics and its AcuStream technology.
2) Pfizer Inc.
Pfizer Inc. is a pharmaceutical and biotechnology company based in America. It was founded in the year 1849. Pfizer manufactures and produces vaccines and medicine related to oncology, neurology, cardiology, and immunology. The corporation has produced various products that yield more than US$1 billion in annual revenue.
The company ranked 64th on the Fortune 500 and 49th on the Forbes Global 2000. The headquarters are located in New York City, U.S. and the products manufactured are sold worldwide. The company was founded by Charles Pfizer and Charles F. Erhart.
In 2022, the company acquired Arena Pharmaceuticals for US$ 6.7 Billion. In October 2022, Pfizer completed the acquisition Biohaven Pharma for US$ 11.6 Billion.
3) AstraZeneca Plc.
AstraZeneca Plc. Is a multinational pharmaceutical and biotechnology company. The company is known for manufacturing products for major diseases like Oncology, Cardiovascular, Infection, Respiratory and Inflammation. Apart from that, it has also been a part of developing the Oxford-AstraZeneca Covid-19 vaccine. The company was founded in 1999 and the headquarters are located in Cambridge, England, UK.
In July of 2021 AstraZeneca completed the acquisition of Alexion Pharmaceuticals, Inc. In January of 2023, AstraZeneca also announced its plans to acquired CinCor a biopharmaceutical company based in the U.S.
4) Sanofi S.A.
Sanofi S.A. is a multinational pharmaceutical company that engages in the research and development, of pharmacological products, in the prescription market. The firm cover therapeutic areas like Cardiovascular, central nervous system, diabetes, internal medicine. The company was founded in 973 and the headquarters are located in Paris, France. Products manufactured include Medications, Genetic drugs, Vaccines, Animal Health, etc.
In December, 2022 Sanofi expanded its collaboration with Innate Pharma, with Sanofi licensing a natural killer (NK) cell nagger program targeting B7H3 from Innate’s ANKET platform.
5) Merck & C. Inc
Merck, is a pharmaceutical institution based in America. The company’s headquarters are situated in Rahway, New Jersey. The company gets its name from Merck Group that was established in Germany in the year 1668. In the year 2022 the company ranked 71st in the Fortune 500 companies list. And based on the revenues of 2021 it took the place as 87th in the Forbes Global 2000.
6) Amgen Inc.
Amgen Inc. (Applied Molecular Genetic Inc.) is a biopharmaceutical company based in America. It is one of the world’s largest biotechnology company. The company was founded in the year 1980 in the 8th of April. The headquarters are located in Thousand Oaks, California, U.S. The company sells its products worldwide and some of them include Aimovig, Enbrel, Prolia, Xgeva, Nplate etc. The company was founded by William K. the company’s largest selling products.
In October Amgen Inc. successfully completed the acquisition of ChemoCentryx, Inc. a biopharmaceutical company.
